Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema
Hyperpolarized 83Kr surface quadrupolar relaxation (SQUARE) generates MRI contrast that was previously shown to correlate to surface to volume ratios in porous model surface systems. The underlying physics of SQUARE contrast is conceptually different from any other current MRI methodology as the met...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Published: |
The Royal Society
2015
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/31548/ |
| _version_ | 1848794224525312000 |
|---|---|
| author | Lilburn, David M.L. Lesbats, Clémentine Six, Joseph S. Dubuis, Eric Yew-Booth, Liang Shaw, Dominick E. Belvisi, Maria G. Birrell, Mark A. Pavlovskaya, Galina E. Meersmann, Thomas |
| author_facet | Lilburn, David M.L. Lesbats, Clémentine Six, Joseph S. Dubuis, Eric Yew-Booth, Liang Shaw, Dominick E. Belvisi, Maria G. Birrell, Mark A. Pavlovskaya, Galina E. Meersmann, Thomas |
| author_sort | Lilburn, David M.L. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Hyperpolarized 83Kr surface quadrupolar relaxation (SQUARE) generates MRI contrast that was previously shown to correlate to surface to volume ratios in porous model surface systems. The underlying physics of SQUARE contrast is conceptually different from any other current MRI methodology as the method utilizes the nuclear electric properties of the spin I = 9/2 isotope 83Kr. To explore the usage of this non-radioactive isotope for pulmonary pathophysiology, MRI SQUARE contrast was acquired in excised rat lungs obtained from an elastase induced model of emphysema. A significant 83Kr T1 relaxation time increase in the SQUARE contrast was found in the elastase treated lungs compared to the baseline data from control lungs. The SQUARE contrast suggests a reduction in pulmonary surface to volume ratio in the emphysema model that was validated by histology. The finding supports usage of 83Kr SQUARE as new biomarker for surface to volume ratio changes in emphysema. |
| first_indexed | 2025-11-14T19:12:48Z |
| format | Article |
| id | nottingham-31548 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:12:48Z |
| publishDate | 2015 |
| publisher | The Royal Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-315482020-05-04T17:08:23Z https://eprints.nottingham.ac.uk/31548/ Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema Lilburn, David M.L. Lesbats, Clémentine Six, Joseph S. Dubuis, Eric Yew-Booth, Liang Shaw, Dominick E. Belvisi, Maria G. Birrell, Mark A. Pavlovskaya, Galina E. Meersmann, Thomas Hyperpolarized 83Kr surface quadrupolar relaxation (SQUARE) generates MRI contrast that was previously shown to correlate to surface to volume ratios in porous model surface systems. The underlying physics of SQUARE contrast is conceptually different from any other current MRI methodology as the method utilizes the nuclear electric properties of the spin I = 9/2 isotope 83Kr. To explore the usage of this non-radioactive isotope for pulmonary pathophysiology, MRI SQUARE contrast was acquired in excised rat lungs obtained from an elastase induced model of emphysema. A significant 83Kr T1 relaxation time increase in the SQUARE contrast was found in the elastase treated lungs compared to the baseline data from control lungs. The SQUARE contrast suggests a reduction in pulmonary surface to volume ratio in the emphysema model that was validated by histology. The finding supports usage of 83Kr SQUARE as new biomarker for surface to volume ratio changes in emphysema. The Royal Society 2015-05-20 Article PeerReviewed Lilburn, David M.L., Lesbats, Clémentine, Six, Joseph S., Dubuis, Eric, Yew-Booth, Liang, Shaw, Dominick E., Belvisi, Maria G., Birrell, Mark A., Pavlovskaya, Galina E. and Meersmann, Thomas (2015) Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema. Journal of the Royal Society Interface, 12 (107). 20150192/1-20150192/12. ISSN 1742-5689 krypton-83; hyperpolarized noble gas MRI; pulmonary imaging; surface sensitive contrast; animal model emphysema; nuclear electric quadrupolar relaxation http://rsif.royalsocietypublishing.org/content/12/107/20150192 doi:10.1098/rsif.2015.0192 doi:10.1098/rsif.2015.0192 |
| spellingShingle | krypton-83; hyperpolarized noble gas MRI; pulmonary imaging; surface sensitive contrast; animal model emphysema; nuclear electric quadrupolar relaxation Lilburn, David M.L. Lesbats, Clémentine Six, Joseph S. Dubuis, Eric Yew-Booth, Liang Shaw, Dominick E. Belvisi, Maria G. Birrell, Mark A. Pavlovskaya, Galina E. Meersmann, Thomas Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema |
| title | Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema |
| title_full | Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema |
| title_fullStr | Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema |
| title_full_unstemmed | Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema |
| title_short | Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema |
| title_sort | hyperpolarized 83kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema |
| topic | krypton-83; hyperpolarized noble gas MRI; pulmonary imaging; surface sensitive contrast; animal model emphysema; nuclear electric quadrupolar relaxation |
| url | https://eprints.nottingham.ac.uk/31548/ https://eprints.nottingham.ac.uk/31548/ https://eprints.nottingham.ac.uk/31548/ |