Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized 83Kr
Hyperpolarized 83Kr has previously been demonstrated to enable MRI contrast that is sensitive to the chemical composition of the surface in a porous model system. Methodological advances have lead to a substantial increase in the 83Kr hyperpolarization and the resulting signal intensity. Using the i...
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| Format: | Article |
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Elsevier
2014
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| Online Access: | https://eprints.nottingham.ac.uk/31547/ |
| _version_ | 1848794224256876544 |
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| author | Six, Joseph S. Hughes-Riley, Theodore Lilburn, David M.L. Dorkes, Alan C. Stupic, Karl F. Shaw, Dominick E. Morris, Peter G. Hall, Ian P. Pavlovskaya, Galina E. Meersmann, Thomas |
| author_facet | Six, Joseph S. Hughes-Riley, Theodore Lilburn, David M.L. Dorkes, Alan C. Stupic, Karl F. Shaw, Dominick E. Morris, Peter G. Hall, Ian P. Pavlovskaya, Galina E. Meersmann, Thomas |
| author_sort | Six, Joseph S. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Hyperpolarized 83Kr has previously been demonstrated to enable MRI contrast that is sensitive to the chemical composition of the surface in a porous model system. Methodological advances have lead to a substantial increase in the 83Kr hyperpolarization and the resulting signal intensity. Using the improved methodology for spin exchange optical pumping of isotopically enriched 83Kr, internal anatomical details of ex vivo rodent lung were resolved with hyperpolarized 83Kr MRI after krypton inhalation. Different 83Kr relaxation times were found between the main bronchi and the parenchymal regions in ex vivo rat lungs. The T1 weighted hyperpolarized 83Kr MRI provided a first demonstration of surface quadrupolar relaxation (SQUARE) pulmonary MRI contrast. |
| first_indexed | 2025-11-14T19:12:47Z |
| format | Article |
| id | nottingham-31547 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:12:47Z |
| publishDate | 2014 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-315472020-05-04T16:40:22Z https://eprints.nottingham.ac.uk/31547/ Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized 83Kr Six, Joseph S. Hughes-Riley, Theodore Lilburn, David M.L. Dorkes, Alan C. Stupic, Karl F. Shaw, Dominick E. Morris, Peter G. Hall, Ian P. Pavlovskaya, Galina E. Meersmann, Thomas Hyperpolarized 83Kr has previously been demonstrated to enable MRI contrast that is sensitive to the chemical composition of the surface in a porous model system. Methodological advances have lead to a substantial increase in the 83Kr hyperpolarization and the resulting signal intensity. Using the improved methodology for spin exchange optical pumping of isotopically enriched 83Kr, internal anatomical details of ex vivo rodent lung were resolved with hyperpolarized 83Kr MRI after krypton inhalation. Different 83Kr relaxation times were found between the main bronchi and the parenchymal regions in ex vivo rat lungs. The T1 weighted hyperpolarized 83Kr MRI provided a first demonstration of surface quadrupolar relaxation (SQUARE) pulmonary MRI contrast. Elsevier 2014-01-01 Article PeerReviewed Six, Joseph S., Hughes-Riley, Theodore, Lilburn, David M.L., Dorkes, Alan C., Stupic, Karl F., Shaw, Dominick E., Morris, Peter G., Hall, Ian P., Pavlovskaya, Galina E. and Meersmann, Thomas (2014) Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized 83Kr. Magnetic Resonance Imaging, 32 (1). pp. 48-53. ISSN 1873-5894 83Kr; Krypton-83; Kr-83 hyperpolarization; Hyperpolarized; Noble gas MRI; Spin polarization; Cryogenic separation; Spin-exchange optical pumping; Nuclear electric quadrupole moment; Quadrupolar relaxation; Surface sensitive contrast; Pre-clinical MRI; Pulmonary MRI; Lung surfactant http://www.sciencedirect.com/science/article/pii/S0730725X13002890 doi:10.1016/j.mri.2013.08.007 doi:10.1016/j.mri.2013.08.007 |
| spellingShingle | 83Kr; Krypton-83; Kr-83 hyperpolarization; Hyperpolarized; Noble gas MRI; Spin polarization; Cryogenic separation; Spin-exchange optical pumping; Nuclear electric quadrupole moment; Quadrupolar relaxation; Surface sensitive contrast; Pre-clinical MRI; Pulmonary MRI; Lung surfactant Six, Joseph S. Hughes-Riley, Theodore Lilburn, David M.L. Dorkes, Alan C. Stupic, Karl F. Shaw, Dominick E. Morris, Peter G. Hall, Ian P. Pavlovskaya, Galina E. Meersmann, Thomas Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized 83Kr |
| title | Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized 83Kr |
| title_full | Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized 83Kr |
| title_fullStr | Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized 83Kr |
| title_full_unstemmed | Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized 83Kr |
| title_short | Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized 83Kr |
| title_sort | pulmonary mri contrast using surface quadrupolar relaxation (square) of hyperpolarized 83kr |
| topic | 83Kr; Krypton-83; Kr-83 hyperpolarization; Hyperpolarized; Noble gas MRI; Spin polarization; Cryogenic separation; Spin-exchange optical pumping; Nuclear electric quadrupole moment; Quadrupolar relaxation; Surface sensitive contrast; Pre-clinical MRI; Pulmonary MRI; Lung surfactant |
| url | https://eprints.nottingham.ac.uk/31547/ https://eprints.nottingham.ac.uk/31547/ https://eprints.nottingham.ac.uk/31547/ |