Smoke-free legislation and the incidence of paediatric respiratory infections and wheezing/asthma: interrupted time series analyses in the four UK nations
We investigated the association between introduction of smoke-free legislation in the UK (March 2006 for Scotland, April 2007 for Wales and Northern Ireland, and July 2007 for England) and the incidence of respiratory diseases among children. We extracted monthly counts of new diagnoses of wheezing/...
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| Format: | Article |
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Nature Publishing Group
2015
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| Online Access: | https://eprints.nottingham.ac.uk/31351/ |
| _version_ | 1848794182780452864 |
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| author | Been, Jasper V. Szatkowski, Lisa Staa, Tjeerd-Pieter van Leufkens, Hubert G. Schayck, Onno C. van Sheikh, Aziz Vries, Frank de Souverein, Patrick |
| author_facet | Been, Jasper V. Szatkowski, Lisa Staa, Tjeerd-Pieter van Leufkens, Hubert G. Schayck, Onno C. van Sheikh, Aziz Vries, Frank de Souverein, Patrick |
| author_sort | Been, Jasper V. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | We investigated the association between introduction of smoke-free legislation in the UK (March 2006 for Scotland, April 2007 for Wales and Northern Ireland, and July 2007 for England) and the incidence of respiratory diseases among children. We extracted monthly counts of new diagnoses of wheezing/asthma and RTIs among children aged 0–12 years from all general practices in the Clinical Practice Research Datalink during 1997–2012. Interrupted time series analyses were performed using generalised additive mixed models, adjusting for underlying incidence trends, population size changes, seasonal factors, and pandemic influenza, as appropriate. 366,642 new wheezing/asthma diagnoses and 4,324,789 RTIs were observed over 9,536,003 patient-years. There was no statistically significant change in the incidence of wheezing/asthma after introduction of smoke-free legislation in England (incidence rate ratio (IRR) 0.94, 95% CI 0.81–1.09) or any other UK country (Scotland: IRR 0.99, 95% CI 0.83–1.19; Wales: IRR 1.09, 95% CI 0.89–1.35; Northern Ireland: IRR 0.96, 95% CI 0.76–1.22). Similarly no statistically significant changes in RTI incidence were demonstrated (England: IRR 0.95, 95% CI 0.86–1.06; Scotland: IRR 0.96, 95% CI 0.83–1.11; Wales: IRR 0.97, 95% CI 0.86–1.09; Northern Ireland: IRR 0.90, 95% CI 0.79–1.03). There were no demonstrable reductions in the incidence of paediatric wheezing/asthma or RTIs following introduction of smoke-free legislation in the UK. |
| first_indexed | 2025-11-14T19:12:08Z |
| format | Article |
| id | nottingham-31351 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:12:08Z |
| publishDate | 2015 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-313512020-05-04T17:19:40Z https://eprints.nottingham.ac.uk/31351/ Smoke-free legislation and the incidence of paediatric respiratory infections and wheezing/asthma: interrupted time series analyses in the four UK nations Been, Jasper V. Szatkowski, Lisa Staa, Tjeerd-Pieter van Leufkens, Hubert G. Schayck, Onno C. van Sheikh, Aziz Vries, Frank de Souverein, Patrick We investigated the association between introduction of smoke-free legislation in the UK (March 2006 for Scotland, April 2007 for Wales and Northern Ireland, and July 2007 for England) and the incidence of respiratory diseases among children. We extracted monthly counts of new diagnoses of wheezing/asthma and RTIs among children aged 0–12 years from all general practices in the Clinical Practice Research Datalink during 1997–2012. Interrupted time series analyses were performed using generalised additive mixed models, adjusting for underlying incidence trends, population size changes, seasonal factors, and pandemic influenza, as appropriate. 366,642 new wheezing/asthma diagnoses and 4,324,789 RTIs were observed over 9,536,003 patient-years. There was no statistically significant change in the incidence of wheezing/asthma after introduction of smoke-free legislation in England (incidence rate ratio (IRR) 0.94, 95% CI 0.81–1.09) or any other UK country (Scotland: IRR 0.99, 95% CI 0.83–1.19; Wales: IRR 1.09, 95% CI 0.89–1.35; Northern Ireland: IRR 0.96, 95% CI 0.76–1.22). Similarly no statistically significant changes in RTI incidence were demonstrated (England: IRR 0.95, 95% CI 0.86–1.06; Scotland: IRR 0.96, 95% CI 0.83–1.11; Wales: IRR 0.97, 95% CI 0.86–1.09; Northern Ireland: IRR 0.90, 95% CI 0.79–1.03). There were no demonstrable reductions in the incidence of paediatric wheezing/asthma or RTIs following introduction of smoke-free legislation in the UK. Nature Publishing Group 2015-10-14 Article PeerReviewed Been, Jasper V., Szatkowski, Lisa, Staa, Tjeerd-Pieter van, Leufkens, Hubert G., Schayck, Onno C. van, Sheikh, Aziz, Vries, Frank de and Souverein, Patrick (2015) Smoke-free legislation and the incidence of paediatric respiratory infections and wheezing/asthma: interrupted time series analyses in the four UK nations. Scientific Reports, 5 . 15246/1-15246/10. ISSN 2045-2322 Health policy Paediatric research Preventive medicine http://www.nature.com/articles/srep15246 doi:10.1038/srep15246 doi:10.1038/srep15246 |
| spellingShingle | Health policy Paediatric research Preventive medicine Been, Jasper V. Szatkowski, Lisa Staa, Tjeerd-Pieter van Leufkens, Hubert G. Schayck, Onno C. van Sheikh, Aziz Vries, Frank de Souverein, Patrick Smoke-free legislation and the incidence of paediatric respiratory infections and wheezing/asthma: interrupted time series analyses in the four UK nations |
| title | Smoke-free legislation and the incidence of paediatric respiratory infections and wheezing/asthma: interrupted time series analyses in the four UK nations |
| title_full | Smoke-free legislation and the incidence of paediatric respiratory infections and wheezing/asthma: interrupted time series analyses in the four UK nations |
| title_fullStr | Smoke-free legislation and the incidence of paediatric respiratory infections and wheezing/asthma: interrupted time series analyses in the four UK nations |
| title_full_unstemmed | Smoke-free legislation and the incidence of paediatric respiratory infections and wheezing/asthma: interrupted time series analyses in the four UK nations |
| title_short | Smoke-free legislation and the incidence of paediatric respiratory infections and wheezing/asthma: interrupted time series analyses in the four UK nations |
| title_sort | smoke-free legislation and the incidence of paediatric respiratory infections and wheezing/asthma: interrupted time series analyses in the four uk nations |
| topic | Health policy Paediatric research Preventive medicine |
| url | https://eprints.nottingham.ac.uk/31351/ https://eprints.nottingham.ac.uk/31351/ https://eprints.nottingham.ac.uk/31351/ |