Seven-membered ring scaffolds for drug discovery: access to functionalised azepanes and oxepanes through diazocarbonyl chemistry

QR Code

Seven-membered ring scaffolds for drug discovery: access to functionalised azepanes and oxepanes through diazocarbonyl chemistry

Functionalised azepane and oxepane scaffolds were prepared using diazocarbonyl chemistry and elaborated to show their potential use in library synthesis. Key dicarbonyl containing seven-membered rings were functionalised via diastereoselective Luche reduction of the ketone followed by manipulation o...

Full description

Bibliographic Details
Main Authors:	Nortcliffe, Andrew, Moody, Christopher J.
Format:	Article
Published:	Elsevier 2015
Subjects:	Seven-Membered Rings Azepane Oxepane Diazocarbonyl Medicinal Chemistry
Online Access:	https://eprints.nottingham.ac.uk/30957/

Similar Items

Recent Synthetic Strategies to Access Seven-Membered Carbocycles in Natural Product Synthesis
by: Nguyen, Thanh Vinh, et al.
Published: (2013)

Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery
by: Geary, Gemma C., et al.
Published: (2017)

Risk, networks and privateering in Liverpool during the Seven Years War, 1756-1763
by: Haggerty, Sheryllynne
Published: (2018)

Skew Armendariz rings and their relations
by: Pourtaherian, Hamideh
Published: (2012)

Assessment of mitral valve geometry for personalised annuloplasty ring development
by: Srisook, Chirattikan
Published: (2024)

Synthesis of highly substituted 1,2-diazetidin-3-ones, small ring scaffolds for drug discovery
by: Santos, Marilla S., et al.
Published: (2018)

Small ring testing of high temperature materials
by: Hyde, Christopher J., et al.
Published: (2017)

Boolean routing on high degree chordal ring networks
by: Matroud Bashi, Atheer Abbas
Published: (2001)

A new measuring method for friction factor by using ring with inner boss compression test
by: Hu, Chengliang, et al.
Published: (2017)

Diversification of ortho-fused cycloocta-2,5-dien-1-one cores and 8 to 6-Ring conversion by sigma bond C-C cleavage
by: Eccleshare, Lee, et al.
Published: (2016)

"Victim, survivor, thriver": An exploration of the perceptions and experiences of females previously affiliated with gangs
by: Lowe, Olivia
Published: (2022)

Modeling and optimization of microwave ring resonator filters using CST software
by: Zhu, Zhongdao
Published: (2013)

Geoid computations using ring integration: gridded versus point data
by: Kirby, Jonathan, et al.
Published: (1997)

Controlled ring-opening polymerisation using microwave heating
by: Deng, Ei Leen
Published: (2016)

Vortex rings in axially rotating fluids
by: Terry, Helen
Published: (2019)

Bumps and rings in a two-dimensional neural field: splitting and rotational instabilities
by: Owen, Markus R., et al.
Published: (2007)

Foraging Pattern, Functional and Numerical Response of Coccinella Septempunctata (L.) Feeding on Myzus Persicae (Sulzer.)
by: Khan, Muhammad Rahim
Published: (2003)

Spin polarization of carriers in InGaAs self-assembled quantum rings inserted in GaAs-AlGaAs resonant tunneling devices
by: Gordo, V. Orsi, et al.
Published: (2017)

An investigation on thermoelastic damping of high-Q ring resonators
by: Hossain, Syed T., et al.
Published: (2016)

Ring opening polymerisation of ɛ-caprolactone using microwave electric and magnetic heating
by: Wang, Kaiyang
Published: (2018)

Resource management algorithms for wavelength division multiplexing optical metro slotted ring networks
by: Mohammed Abdulrazak, Fuaad Hasan
Published: (2012)

C–H insertion as a key step to spiro-oxetanes, scaffolds for drug discovery
by: Nicolle, Simon M., et al.
Published: (2017)

Small ring testing of a creep resistant material
by: Hyde, Christopher J., et al.
Published: (2013)

Intercultural Interactions: Understanding the Perspectives of University Staff Members, International and Domestic Students
by: Harryba, S., et al.
Published: (2013)

The effect of Mn on mineral stability in metapelites revisited: new a–x relations for manganese-bearing minerals
by: White, R., et al.
Published: (2014)

Seismic assessment of a heavy-timber frame structure with ring-doweled moment-resisting connections
by: Rodrigues, Leonardo G., et al.
Published: (2017)

Evaluating Group Member Behaviour Under Individualist and Collectivist Norms: A Cross-Cultural Comparison
by: Hagger, Martin, et al.
Published: (2014)

Effect of nonlinear electrostatic forces on the dynamic behaviour of a capacitive ring-based Coriolis Vibrating Gyroscope under severe shock
by: Chouvion, B., et al.
Published: (2018)

Silver(I)-Catalysed Synthesis of Cuneanes from Cubanes and their Investigation as Isosteres
by: Smith, Elliot J.
Published: (2024)

Social Comparisons, Self-Conceptions, and Attributions: Assessing the Self-Related Contingencies in Leader-Member Exchange Relationships
by: Lapointe, Émilie, et al.
Published: (2019)

‘The longest suicide vote in history’: the Labour Party leadership election of 2015
by: Dorey, Peter, et al.
Published: (2016)

Finite nonassociative algebras obtained from skew polynomials and possible applications to (f, σ, δ)-codes
by: Pumpluen, Susanne
Published: (2017)

Tales of the unexpected: the selection of British party leaders since 1963
by: Denham, Andrew, et al.
Published: (2018)

An ever-closer union?: measuring the expansion and ideological content of European Union policy-making through an expert survey
by: Nanou, Kyriaki, et al.
Published: (2017)

Feature, Structure and Classification of Adhesion Molecules: An Overview
by: Coombe, Deirdre, et al.
Published: (2010)

On the right nucleus of Petit algebras
by: Owen, Adam
Published: (2022)

Anionic polymerisation of caprolactam at the small-scale via DSC investigations
by: Khodabakhshi, Khosrow, et al.
Published: (2013)

New classes of nonassociative divison algebras and MRD codes
by: Thompson, Daniel
Published: (2021)

Exploring the Experiences of Family Members When a Patient Is Admitted to the ICU with a Severe Traumatic Brain Injury: A Scoping Review
by: Hayes, K., et al.
Published: (2023)

Clinical and biological roles of Kelch-like family member 7 in breast cancer: a marker of poor prognosis
by: Kurozumi, Sasagu, et al.
Published: (2018)