Engineering serendipity: high-throughput discovery of materials that resist bacterial attachment
Controlling the colonisation of materials by microorganisms is important in a wide range of industries and clinical settings. To date, the underlying mechanisms that govern the interactions of bacteria with material surfaces remain poorly understood, limiting the ab initio design and engineering of...
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| Format: | Article |
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Elsevier
2016
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| Online Access: | https://eprints.nottingham.ac.uk/30948/ |
| _version_ | 1848794097014276096 |
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| author | Magennis, E.P. Hook, A.L. Davies, M.C. Alexander, C. Williams, P. Alexander, Morgan R. |
| author_facet | Magennis, E.P. Hook, A.L. Davies, M.C. Alexander, C. Williams, P. Alexander, Morgan R. |
| author_sort | Magennis, E.P. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Controlling the colonisation of materials by microorganisms is important in a wide range of industries and clinical settings. To date, the underlying mechanisms that govern the interactions of bacteria with material surfaces remain poorly understood, limiting the ab initio design and engineering of biomaterials to control bacterial attachment. Combinatorial approaches involving high-throughput screening have emerged as key tools for identifying materials to control bacterial attachment. The hundreds of different materials assessed using these methods can be carried out with the aid of computational modelling. This approach can develop an understanding of the rules used to predict bacterial attachment to surfaces of non-toxic synthetic materials. Here we outline our view on the state of this field and the challenges and opportunities in this area for the coming years. |
| first_indexed | 2025-11-14T19:10:46Z |
| format | Article |
| id | nottingham-30948 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:10:46Z |
| publishDate | 2016 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-309482020-05-04T17:39:00Z https://eprints.nottingham.ac.uk/30948/ Engineering serendipity: high-throughput discovery of materials that resist bacterial attachment Magennis, E.P. Hook, A.L. Davies, M.C. Alexander, C. Williams, P. Alexander, Morgan R. Controlling the colonisation of materials by microorganisms is important in a wide range of industries and clinical settings. To date, the underlying mechanisms that govern the interactions of bacteria with material surfaces remain poorly understood, limiting the ab initio design and engineering of biomaterials to control bacterial attachment. Combinatorial approaches involving high-throughput screening have emerged as key tools for identifying materials to control bacterial attachment. The hundreds of different materials assessed using these methods can be carried out with the aid of computational modelling. This approach can develop an understanding of the rules used to predict bacterial attachment to surfaces of non-toxic synthetic materials. Here we outline our view on the state of this field and the challenges and opportunities in this area for the coming years. Elsevier 2016-04-01 Article PeerReviewed Magennis, E.P., Hook, A.L., Davies, M.C., Alexander, C., Williams, P. and Alexander, Morgan R. (2016) Engineering serendipity: high-throughput discovery of materials that resist bacterial attachment. Acta Biomaterialia, 34 . pp. 84-92. ISSN 1878-7568 Biomaterials Bacteria High-throughput Biofilm Polymers http://www.sciencedirect.com/science/article/pii/S1742706115301859 doi:10.1016/j.actbio.2015.11.008 doi:10.1016/j.actbio.2015.11.008 |
| spellingShingle | Biomaterials Bacteria High-throughput Biofilm Polymers Magennis, E.P. Hook, A.L. Davies, M.C. Alexander, C. Williams, P. Alexander, Morgan R. Engineering serendipity: high-throughput discovery of materials that resist bacterial attachment |
| title | Engineering serendipity: high-throughput discovery of materials that resist bacterial attachment |
| title_full | Engineering serendipity: high-throughput discovery of materials that resist bacterial attachment |
| title_fullStr | Engineering serendipity: high-throughput discovery of materials that resist bacterial attachment |
| title_full_unstemmed | Engineering serendipity: high-throughput discovery of materials that resist bacterial attachment |
| title_short | Engineering serendipity: high-throughput discovery of materials that resist bacterial attachment |
| title_sort | engineering serendipity: high-throughput discovery of materials that resist bacterial attachment |
| topic | Biomaterials Bacteria High-throughput Biofilm Polymers |
| url | https://eprints.nottingham.ac.uk/30948/ https://eprints.nottingham.ac.uk/30948/ https://eprints.nottingham.ac.uk/30948/ |