Genome-wide profiling in treatment-naive early rheumatoid arthritis reveals DNA methylome changes in T and B lymphocytes

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Genome-wide profiling in treatment-naive early rheumatoid arthritis reveals DNA methylome changes in T and B lymphocytes

AIM: Although aberrant DNA methylation has been described in rheumatoid arthritis (RA), no studies have interrogated this epigenetic modification in early disease. Following recent investigations of T- and B-lymphocytes in established disease, we now characterize in these cell populations genome-wid...

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Bibliographic Details
Main Authors:	Glossop, John R., Emes, Richard D., Nixon, Nicola B., Packham, Jon C., Fryer, Anthony A., Mattey, Derek L., Farrell, William E.
Format:	Article
Published:	Future Medicine 2016
Subjects:	Early rheumatoid arthritis; Treatment-naïve; DNA methylation; T-lymphocyte; B-lymphocyte; CpG; Genome-wide; Illumina 450K array.
Online Access:	https://eprints.nottingham.ac.uk/30944/

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