High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry
Switchable materials that alter their chemical or physical properties in response to external stimuli allow for temporal control of material-biological interactions, thus, are of interest for many biomaterial applications. Our interest is the discovery of new materials suitable to the specific requi...
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| Format: | Article |
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Wiley
2013
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| Online Access: | https://eprints.nottingham.ac.uk/30929/ |
| _version_ | 1848794092929024000 |
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| author | Hook, Andrew L. Scurr, David J. Anderson, Daniel G. Langer, Robert Williams, Paul Davies, Martyn C. Alexander, Morgan R. |
| author_facet | Hook, Andrew L. Scurr, David J. Anderson, Daniel G. Langer, Robert Williams, Paul Davies, Martyn C. Alexander, Morgan R. |
| author_sort | Hook, Andrew L. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Switchable materials that alter their chemical or physical properties in response to external stimuli allow for temporal control of material-biological interactions, thus, are of interest for many biomaterial applications. Our interest is the discovery of new materials suitable to the specific requirements of certain biological systems. A high throughput methodology has been developed to screen a library of polymers for thermo-responsiveness, which has resulted in the identification of novel switchable materials. To elucidate the mechanism by which the materials switch, time-of-flight secondary ion mass spectrometry has been employed to analyse the top 2 nm of the polymer samples at different temperatures. The surface enrichment of certain molecular fragments has been identified by time-of-flight secondary ion mass spectrometry analysis at different temperatures, suggesting an altered molecular conformation. In one example, a switch between an extended and collapsed conformation is inferred. |
| first_indexed | 2025-11-14T19:10:42Z |
| format | Article |
| id | nottingham-30929 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:10:42Z |
| publishDate | 2013 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-309292020-05-04T20:19:42Z https://eprints.nottingham.ac.uk/30929/ High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry Hook, Andrew L. Scurr, David J. Anderson, Daniel G. Langer, Robert Williams, Paul Davies, Martyn C. Alexander, Morgan R. Switchable materials that alter their chemical or physical properties in response to external stimuli allow for temporal control of material-biological interactions, thus, are of interest for many biomaterial applications. Our interest is the discovery of new materials suitable to the specific requirements of certain biological systems. A high throughput methodology has been developed to screen a library of polymers for thermo-responsiveness, which has resulted in the identification of novel switchable materials. To elucidate the mechanism by which the materials switch, time-of-flight secondary ion mass spectrometry has been employed to analyse the top 2 nm of the polymer samples at different temperatures. The surface enrichment of certain molecular fragments has been identified by time-of-flight secondary ion mass spectrometry analysis at different temperatures, suggesting an altered molecular conformation. In one example, a switch between an extended and collapsed conformation is inferred. Wiley 2013-01 Article PeerReviewed Hook, Andrew L., Scurr, David J., Anderson, Daniel G., Langer, Robert, Williams, Paul, Davies, Martyn C. and Alexander, Morgan R. (2013) High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry. Surface and Interface Analysis, 45 (1). pp. 181-184. ISSN 1096-9918 Thermo-Responsive Stimuli Switchable ToF-SIMS Water Contact Angle Polymer Microarray http://onlinelibrary.wiley.com/doi/10.1002/sia.4910/abstract doi:10.1002/sia.4910 doi:10.1002/sia.4910 |
| spellingShingle | Thermo-Responsive Stimuli Switchable ToF-SIMS Water Contact Angle Polymer Microarray Hook, Andrew L. Scurr, David J. Anderson, Daniel G. Langer, Robert Williams, Paul Davies, Martyn C. Alexander, Morgan R. High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry |
| title | High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry |
| title_full | High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry |
| title_fullStr | High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry |
| title_full_unstemmed | High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry |
| title_short | High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry |
| title_sort | high throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry |
| topic | Thermo-Responsive Stimuli Switchable ToF-SIMS Water Contact Angle Polymer Microarray |
| url | https://eprints.nottingham.ac.uk/30929/ https://eprints.nottingham.ac.uk/30929/ https://eprints.nottingham.ac.uk/30929/ |