Knockdown of the C. elegans kinome identifies kinases required for normal protein homeostasis, mitochondrial network structure, and sarcomere structure in muscle
Kinases are important signalling molecules for modulating cellular processes and major targets of drug discovery programs. However, functional information for roughly half the human kinome is lacking. We conducted three kinome wide, >90%, RNAi screens and epistasis testing of some identified kina...
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| Format: | Article |
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BioMed Central
2013
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| Online Access: | https://eprints.nottingham.ac.uk/3089/ |
| _version_ | 1848790951213924352 |
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| author | Lehmann, Susann Bass, Joseph J. Szewczyk, N.J. |
| author_facet | Lehmann, Susann Bass, Joseph J. Szewczyk, N.J. |
| author_sort | Lehmann, Susann |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Kinases are important signalling molecules for modulating cellular processes and major targets of drug discovery programs. However, functional information for roughly half the human kinome is lacking. We conducted three kinome wide, >90%, RNAi screens and epistasis testing of some identified kinases against known intramuscular signalling systems to increase the functional annotation of the C. elegans kinome and expand our understanding of kinome influence upon muscle protein degradation. |
| first_indexed | 2025-11-14T18:20:46Z |
| format | Article |
| id | nottingham-3089 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:20:46Z |
| publishDate | 2013 |
| publisher | BioMed Central |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-30892020-05-04T16:38:48Z https://eprints.nottingham.ac.uk/3089/ Knockdown of the C. elegans kinome identifies kinases required for normal protein homeostasis, mitochondrial network structure, and sarcomere structure in muscle Lehmann, Susann Bass, Joseph J. Szewczyk, N.J. Kinases are important signalling molecules for modulating cellular processes and major targets of drug discovery programs. However, functional information for roughly half the human kinome is lacking. We conducted three kinome wide, >90%, RNAi screens and epistasis testing of some identified kinases against known intramuscular signalling systems to increase the functional annotation of the C. elegans kinome and expand our understanding of kinome influence upon muscle protein degradation. BioMed Central 2013-09-23 Article PeerReviewed Lehmann, Susann, Bass, Joseph J. and Szewczyk, N.J. (2013) Knockdown of the C. elegans kinome identifies kinases required for normal protein homeostasis, mitochondrial network structure, and sarcomere structure in muscle. Cell Communication & Signaling, 11 (71). ISSN 1478-811X http://www.biosignaling.com/content/11/1/71 doi:10.1186/1478-811X-11-71 doi:10.1186/1478-811X-11-71 |
| spellingShingle | Lehmann, Susann Bass, Joseph J. Szewczyk, N.J. Knockdown of the C. elegans kinome identifies kinases required for normal protein homeostasis, mitochondrial network structure, and sarcomere structure in muscle |
| title | Knockdown of the C. elegans kinome identifies kinases required for normal protein homeostasis, mitochondrial network structure, and sarcomere structure in muscle |
| title_full | Knockdown of the C. elegans kinome identifies kinases required for normal protein homeostasis, mitochondrial network structure, and sarcomere structure in muscle |
| title_fullStr | Knockdown of the C. elegans kinome identifies kinases required for normal protein homeostasis, mitochondrial network structure, and sarcomere structure in muscle |
| title_full_unstemmed | Knockdown of the C. elegans kinome identifies kinases required for normal protein homeostasis, mitochondrial network structure, and sarcomere structure in muscle |
| title_short | Knockdown of the C. elegans kinome identifies kinases required for normal protein homeostasis, mitochondrial network structure, and sarcomere structure in muscle |
| title_sort | knockdown of the c. elegans kinome identifies kinases required for normal protein homeostasis, mitochondrial network structure, and sarcomere structure in muscle |
| url | https://eprints.nottingham.ac.uk/3089/ https://eprints.nottingham.ac.uk/3089/ https://eprints.nottingham.ac.uk/3089/ |