Materials for stem cell factories of the future
The materials community is now identifying polymeric substrates that could permit translation of human pluripotent stem cells (hPSCs) from lab-based research to industrial scale biomedicine. Well defined materials are required to allow cell banking and to provide the raw material for reproducible di...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
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Nature Publishing Group
2014
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| Online Access: | https://eprints.nottingham.ac.uk/30875/ |
| _version_ | 1848794081267810304 |
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| author | Celiz, Adam D. Smith, James G.W. Langer, Robert Anderson, Daniel G. Barrett, David A. Winkler, David A. Davies, Martyn C. Young, Lorraine E. Denning, Chris Alexander, Morgan R. |
| author_facet | Celiz, Adam D. Smith, James G.W. Langer, Robert Anderson, Daniel G. Barrett, David A. Winkler, David A. Davies, Martyn C. Young, Lorraine E. Denning, Chris Alexander, Morgan R. |
| author_sort | Celiz, Adam D. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The materials community is now identifying polymeric substrates that could permit translation of human pluripotent stem cells (hPSCs) from lab-based research to industrial scale biomedicine. Well defined materials are required to allow cell banking and to provide the raw material for reproducible differentiation into lineages for large scale drug screening programs and clinical use, wherein >1 billion cells for each patient are needed to replace losses during heart attack, multiple sclerosis and diabetes. Producing this number of cells for one patient is challenging and a rethink is needed to scalable technology with the potential to meet the needs of millions of patients a year. Here we consider the role of materials discovery, an emerging area of materials chemistry that is in a large part driven by the challenges posed by biologists to materials scientists1-4. |
| first_indexed | 2025-11-14T19:10:31Z |
| format | Article |
| id | nottingham-30875 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:10:31Z |
| publishDate | 2014 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-308752020-05-04T16:47:43Z https://eprints.nottingham.ac.uk/30875/ Materials for stem cell factories of the future Celiz, Adam D. Smith, James G.W. Langer, Robert Anderson, Daniel G. Barrett, David A. Winkler, David A. Davies, Martyn C. Young, Lorraine E. Denning, Chris Alexander, Morgan R. The materials community is now identifying polymeric substrates that could permit translation of human pluripotent stem cells (hPSCs) from lab-based research to industrial scale biomedicine. Well defined materials are required to allow cell banking and to provide the raw material for reproducible differentiation into lineages for large scale drug screening programs and clinical use, wherein >1 billion cells for each patient are needed to replace losses during heart attack, multiple sclerosis and diabetes. Producing this number of cells for one patient is challenging and a rethink is needed to scalable technology with the potential to meet the needs of millions of patients a year. Here we consider the role of materials discovery, an emerging area of materials chemistry that is in a large part driven by the challenges posed by biologists to materials scientists1-4. Nature Publishing Group 2014-05-21 Article PeerReviewed Celiz, Adam D., Smith, James G.W., Langer, Robert, Anderson, Daniel G., Barrett, David A., Winkler, David A., Davies, Martyn C., Young, Lorraine E., Denning, Chris and Alexander, Morgan R. (2014) Materials for stem cell factories of the future. Nature Materials, 13 (6). pp. 570-579. ISSN 1476-4660 biomaterials cells human pluripotent stem cells https://www.nature.com/articles/nmat3972 doi:10.1038/nmat3972 doi:10.1038/nmat3972 |
| spellingShingle | biomaterials cells human pluripotent stem cells Celiz, Adam D. Smith, James G.W. Langer, Robert Anderson, Daniel G. Barrett, David A. Winkler, David A. Davies, Martyn C. Young, Lorraine E. Denning, Chris Alexander, Morgan R. Materials for stem cell factories of the future |
| title | Materials for stem cell factories of the future |
| title_full | Materials for stem cell factories of the future |
| title_fullStr | Materials for stem cell factories of the future |
| title_full_unstemmed | Materials for stem cell factories of the future |
| title_short | Materials for stem cell factories of the future |
| title_sort | materials for stem cell factories of the future |
| topic | biomaterials cells human pluripotent stem cells |
| url | https://eprints.nottingham.ac.uk/30875/ https://eprints.nottingham.ac.uk/30875/ https://eprints.nottingham.ac.uk/30875/ |