Antibiotic prescribing in primary care and antimicrobial resistance in patients admitted to hospital with urinary tract infection: a controlled observational pilot study
There is growing evidence that primary care prescribed antibiotics lead to antibiotic resistance in bacteria causing minor infections or being carried by asymptomatic adults, but little research to date has investigated links between primary care prescribed antibiotics and resistance among more seri...
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| Format: | Article |
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Multidisciplinary Digital Publishing Institute
2014
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| Online Access: | https://eprints.nottingham.ac.uk/3082/ |
| _version_ | 1848790949318098944 |
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| author | Costelloe, Ceire Williams, O. Martin Montgomery, Alan A. Dayan, Colin Hay, Alastair D. |
| author_facet | Costelloe, Ceire Williams, O. Martin Montgomery, Alan A. Dayan, Colin Hay, Alastair D. |
| author_sort | Costelloe, Ceire |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | There is growing evidence that primary care prescribed antibiotics lead to antibiotic resistance in bacteria causing minor infections or being carried by asymptomatic adults, but little research to date has investigated links between primary care prescribed antibiotics and resistance among more serious infections requiring hospital care. Knowledge of these effects is likely to have a major influence on public expectations for, and primary care use of, antibiotics. This study aimed to assess the feasibility of recruiting symptomatic adult patients admitted to hospital with urinary infections and to link primary and secondary data information to investigate the relationship between primary care prescribed antibiotics and antimicrobial resistance in these patients. A microbiology database search of in patients who had submitted a urine sample identified 740 patients who were potentially eligible to take part in the study. Of these, 262 patients did not meet the eligibility criteria, mainly due to use of a urinary catheter (40%). Two-hundred and forty three patients could not be recruited as the nurse was unable to visit the patients prior to discharge, as they were too unwell. Eighty patients provided complete information. Results indicate that there is evidence that prior antibiotic use is associated with resistant infections in hospital patients. A fully powered study, conducted using routinely collected data is proposed to fully clarify the precision of the association. |
| first_indexed | 2025-11-14T18:20:44Z |
| format | Article |
| id | nottingham-3082 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:20:44Z |
| publishDate | 2014 |
| publisher | Multidisciplinary Digital Publishing Institute |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-30822020-05-04T16:41:23Z https://eprints.nottingham.ac.uk/3082/ Antibiotic prescribing in primary care and antimicrobial resistance in patients admitted to hospital with urinary tract infection: a controlled observational pilot study Costelloe, Ceire Williams, O. Martin Montgomery, Alan A. Dayan, Colin Hay, Alastair D. There is growing evidence that primary care prescribed antibiotics lead to antibiotic resistance in bacteria causing minor infections or being carried by asymptomatic adults, but little research to date has investigated links between primary care prescribed antibiotics and resistance among more serious infections requiring hospital care. Knowledge of these effects is likely to have a major influence on public expectations for, and primary care use of, antibiotics. This study aimed to assess the feasibility of recruiting symptomatic adult patients admitted to hospital with urinary infections and to link primary and secondary data information to investigate the relationship between primary care prescribed antibiotics and antimicrobial resistance in these patients. A microbiology database search of in patients who had submitted a urine sample identified 740 patients who were potentially eligible to take part in the study. Of these, 262 patients did not meet the eligibility criteria, mainly due to use of a urinary catheter (40%). Two-hundred and forty three patients could not be recruited as the nurse was unable to visit the patients prior to discharge, as they were too unwell. Eighty patients provided complete information. Results indicate that there is evidence that prior antibiotic use is associated with resistant infections in hospital patients. A fully powered study, conducted using routinely collected data is proposed to fully clarify the precision of the association. Multidisciplinary Digital Publishing Institute 2014-01-22 Article PeerReviewed Costelloe, Ceire, Williams, O. Martin, Montgomery, Alan A., Dayan, Colin and Hay, Alastair D. (2014) Antibiotic prescribing in primary care and antimicrobial resistance in patients admitted to hospital with urinary tract infection: a controlled observational pilot study. Antibiotics, 3 (1). pp. 29-38. ISSN 2079-6382 http://www.mdpi.com/2079-6382/3/1/29 doi:10.3390/antibiotics3010029 doi:10.3390/antibiotics3010029 |
| spellingShingle | Costelloe, Ceire Williams, O. Martin Montgomery, Alan A. Dayan, Colin Hay, Alastair D. Antibiotic prescribing in primary care and antimicrobial resistance in patients admitted to hospital with urinary tract infection: a controlled observational pilot study |
| title | Antibiotic prescribing in primary care and antimicrobial resistance in patients admitted to hospital with urinary tract infection: a controlled observational pilot study |
| title_full | Antibiotic prescribing in primary care and antimicrobial resistance in patients admitted to hospital with urinary tract infection: a controlled observational pilot study |
| title_fullStr | Antibiotic prescribing in primary care and antimicrobial resistance in patients admitted to hospital with urinary tract infection: a controlled observational pilot study |
| title_full_unstemmed | Antibiotic prescribing in primary care and antimicrobial resistance in patients admitted to hospital with urinary tract infection: a controlled observational pilot study |
| title_short | Antibiotic prescribing in primary care and antimicrobial resistance in patients admitted to hospital with urinary tract infection: a controlled observational pilot study |
| title_sort | antibiotic prescribing in primary care and antimicrobial resistance in patients admitted to hospital with urinary tract infection: a controlled observational pilot study |
| url | https://eprints.nottingham.ac.uk/3082/ https://eprints.nottingham.ac.uk/3082/ https://eprints.nottingham.ac.uk/3082/ |