The extracellular signal-regulated kinase (ERK) pathway: a potential therapeutic target in hypertension
Hypertension is a risk factor for myocardial infarction, stroke, renal failure, heart failure, and peripheral vascular disease. One feature of hypertension is a hyperresponsiveness to contractile agents, and inhibition of vasoconstriction forms the basis of some of the treatments for hypertension. H...
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| Format: | Article |
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Dove Press
2012
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| Online Access: | https://eprints.nottingham.ac.uk/3079/ |
| _version_ | 1848790948749770752 |
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| author | Roberts, Richard E. |
| author_facet | Roberts, Richard E. |
| author_sort | Roberts, Richard E. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Hypertension is a risk factor for myocardial infarction, stroke, renal failure, heart failure, and peripheral vascular disease. One feature of hypertension is a hyperresponsiveness to contractile agents, and inhibition of vasoconstriction forms the basis of some of the treatments for hypertension. Hypertension is also associated with an increase in the growth and proliferation of vascular smooth muscle cells, which can lead to a thickening of the smooth muscle layer of the blood vessels and a reduction in lumen diameter. Targeting both the enhanced contractile responses, and the increased vascular smooth muscle cell growth could potentially be an important pharmacological treatment of hypertension. Extracellular signal-regulated kinase (ERK) is a member of the mitogen-activated protein kinase family that is involved in both vasoconstriction and vascular smooth muscle cell growth and this, therefore, makes it an attractive therapeutic target for treatment of hypertension. ERK activity is raised in vascular smooth muscle cells from animal models of hypertension, and inhibition of ERK activation reduces both vascular smooth muscle cell growth and vasoconstriction. This review discusses the potential for targeting ERK activity in the treatment of hypertension. |
| first_indexed | 2025-11-14T18:20:44Z |
| format | Article |
| id | nottingham-3079 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:20:44Z |
| publishDate | 2012 |
| publisher | Dove Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-30792020-05-04T16:33:52Z https://eprints.nottingham.ac.uk/3079/ The extracellular signal-regulated kinase (ERK) pathway: a potential therapeutic target in hypertension Roberts, Richard E. Hypertension is a risk factor for myocardial infarction, stroke, renal failure, heart failure, and peripheral vascular disease. One feature of hypertension is a hyperresponsiveness to contractile agents, and inhibition of vasoconstriction forms the basis of some of the treatments for hypertension. Hypertension is also associated with an increase in the growth and proliferation of vascular smooth muscle cells, which can lead to a thickening of the smooth muscle layer of the blood vessels and a reduction in lumen diameter. Targeting both the enhanced contractile responses, and the increased vascular smooth muscle cell growth could potentially be an important pharmacological treatment of hypertension. Extracellular signal-regulated kinase (ERK) is a member of the mitogen-activated protein kinase family that is involved in both vasoconstriction and vascular smooth muscle cell growth and this, therefore, makes it an attractive therapeutic target for treatment of hypertension. ERK activity is raised in vascular smooth muscle cells from animal models of hypertension, and inhibition of ERK activation reduces both vascular smooth muscle cell growth and vasoconstriction. This review discusses the potential for targeting ERK activity in the treatment of hypertension. Dove Press 2012-08-02 Article PeerReviewed Roberts, Richard E. (2012) The extracellular signal-regulated kinase (ERK) pathway: a potential therapeutic target in hypertension. Journal of Experimental Pharmacology, 4 . pp. 77-83. ISSN 1179-1454 https://www.dovepress.com/the-extracellular-signal-regulated-kinase-erk-pathway-a-potential-ther-peer-reviewed-article-JEP-recommendation1 doi:10.2147/JEP.S28907 doi:10.2147/JEP.S28907 |
| spellingShingle | Roberts, Richard E. The extracellular signal-regulated kinase (ERK) pathway: a potential therapeutic target in hypertension |
| title | The extracellular signal-regulated kinase (ERK) pathway: a potential therapeutic target in hypertension |
| title_full | The extracellular signal-regulated kinase (ERK) pathway: a potential therapeutic target in hypertension |
| title_fullStr | The extracellular signal-regulated kinase (ERK) pathway: a potential therapeutic target in hypertension |
| title_full_unstemmed | The extracellular signal-regulated kinase (ERK) pathway: a potential therapeutic target in hypertension |
| title_short | The extracellular signal-regulated kinase (ERK) pathway: a potential therapeutic target in hypertension |
| title_sort | extracellular signal-regulated kinase (erk) pathway: a potential therapeutic target in hypertension |
| url | https://eprints.nottingham.ac.uk/3079/ https://eprints.nottingham.ac.uk/3079/ https://eprints.nottingham.ac.uk/3079/ |