Role of oral teriflunomide in the management of multiple sclerosis
The landscape of the treatment of relapsing–remitting multiple sclerosis is changing fast. Several oral treatments have shown benefit and generate much interest because of the convenience of their administration. Two oral compounds, fingolimod and teriflunomide, have been approved in relapsing–remit...
| Main Authors: | , , |
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| Format: | Article |
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Dove Press
2013
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| Online Access: | https://eprints.nottingham.ac.uk/3057/ |
| _version_ | 1848790943116820480 |
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| author | Tanasescu, Radu Evangelou, Nikos Constantinescu, Cris S. |
| author_facet | Tanasescu, Radu Evangelou, Nikos Constantinescu, Cris S. |
| author_sort | Tanasescu, Radu |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The landscape of the treatment of relapsing–remitting multiple sclerosis is changing fast. Several oral treatments have shown benefit and generate much interest because of the convenience of their administration. Two oral compounds, fingolimod and teriflunomide, have been approved in relapsing–remitting multiple sclerosis, while others have completed Phase III trials and are awaiting review for registration. Teriflunomide is a pyrimidine synthesis inhibitor with selective immunomodulatory and immunosuppressive properties that have shown consistent efficacy in clinical trials, and a good safety profile. This paper provides an overview of the mechanisms of action and efficacy and safety results from clinical trials with this drug. The role of teriflunomide in the treatment of relapsing–remitting multiple sclerosis is discussed. |
| first_indexed | 2025-11-14T18:20:38Z |
| format | Article |
| id | nottingham-3057 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:20:38Z |
| publishDate | 2013 |
| publisher | Dove Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-30572020-05-04T16:36:22Z https://eprints.nottingham.ac.uk/3057/ Role of oral teriflunomide in the management of multiple sclerosis Tanasescu, Radu Evangelou, Nikos Constantinescu, Cris S. The landscape of the treatment of relapsing–remitting multiple sclerosis is changing fast. Several oral treatments have shown benefit and generate much interest because of the convenience of their administration. Two oral compounds, fingolimod and teriflunomide, have been approved in relapsing–remitting multiple sclerosis, while others have completed Phase III trials and are awaiting review for registration. Teriflunomide is a pyrimidine synthesis inhibitor with selective immunomodulatory and immunosuppressive properties that have shown consistent efficacy in clinical trials, and a good safety profile. This paper provides an overview of the mechanisms of action and efficacy and safety results from clinical trials with this drug. The role of teriflunomide in the treatment of relapsing–remitting multiple sclerosis is discussed. Dove Press 2013-04-22 Article PeerReviewed Tanasescu, Radu, Evangelou, Nikos and Constantinescu, Cris S. (2013) Role of oral teriflunomide in the management of multiple sclerosis. Neuropsychiatric Disease and Treatment, 9 . pp. 539-553. ISSN 1176-6328 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639219/ doi:10.2147/NDT.S31248 doi:10.2147/NDT.S31248 |
| spellingShingle | Tanasescu, Radu Evangelou, Nikos Constantinescu, Cris S. Role of oral teriflunomide in the management of multiple sclerosis |
| title | Role of oral teriflunomide in the management of multiple sclerosis |
| title_full | Role of oral teriflunomide in the management of multiple sclerosis |
| title_fullStr | Role of oral teriflunomide in the management of multiple sclerosis |
| title_full_unstemmed | Role of oral teriflunomide in the management of multiple sclerosis |
| title_short | Role of oral teriflunomide in the management of multiple sclerosis |
| title_sort | role of oral teriflunomide in the management of multiple sclerosis |
| url | https://eprints.nottingham.ac.uk/3057/ https://eprints.nottingham.ac.uk/3057/ https://eprints.nottingham.ac.uk/3057/ |