Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor

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Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor

Established therapy in Alzheimer’s disease involves potentiation of the endogenous orthosteric ligand, acetylcholine, at the M1 muscarinic receptors found in higher concentrations in the cortex and hippocampus. Adverse effects, due to indiscriminate activation of other muscarinic receptor subtypes,...

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Bibliographic Details
Main Authors:	Mistry, Shailesh N., Valant, Celine, Sexton, Patrick M., Capuano, Ben, Christopoulos, Arthur, Scammells, Peter J.
Format:	Article
Published:	American Chemical Society 2013
Online Access:	https://eprints.nottingham.ac.uk/30413/

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