Modelling the regulation of telomere length: the effects of telomerase and G-quadruplex stabilising drugs

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Modelling the regulation of telomere length: the effects of telomerase and G-quadruplex stabilising drugs

Telomeres are guanine-rich sequences at the end of chromosomes which shorten during each replication event and trigger cell cycle arrest and/or controlled death (apoptosis) when reaching a threshold length. The enzyme telomerase replenishes the ends of telomeres and thus prolongs the life span of ce...

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Bibliographic Details
Main Authors:	Hirt, Bartholomäus V., Wattis, Jonathan A.D., Preston, Simon P.
Format:	Article
Published:	Springer 2014
Online Access:	https://eprints.nottingham.ac.uk/3036/

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