A mathematical model of the human metabolic system and metabolic flexibility
In healthy subjects some tissues in the human body display metabolic flexibility, by this we mean the ability for the tissue to switch its fuel source between predominantly carbohydrates in the post prandial state and predominantly fats in the fasted state. Many of the pathways involved with human m...
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| Format: | Article |
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Springer
2014
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| Online Access: | https://eprints.nottingham.ac.uk/29802/ |
| _version_ | 1848793855487377408 |
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| author | Pearson, Taliesin Wattis, Jonathan A.D. King, John. R. MacDonald, Ian A. Mazzatti, Dawn |
| author_facet | Pearson, Taliesin Wattis, Jonathan A.D. King, John. R. MacDonald, Ian A. Mazzatti, Dawn |
| author_sort | Pearson, Taliesin |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | In healthy subjects some tissues in the human body display metabolic flexibility, by this we mean the ability for the tissue to switch its fuel source between predominantly carbohydrates in the post prandial state and predominantly fats in the fasted state. Many of the pathways involved with human metabolism are controlled by insulin, and insulin- resistant states such as obesity and type-2 diabetes are characterised by a loss or impairment of metabolic flexibility.
In this paper we derive a system of 12 first-order coupled differential equations that describe the transport between and storage in different tissues of the human body. We find steady state solutions to these equations and use these results to nondimensionalise the model. We then solve the model numerically to simulate a healthy balanced meal and a high fat meal and we discuss and compare these results. Our numerical results show good agreement with experimental data where we have data available to us and the results show behaviour that agrees with intuition where we currently have no data with which to compare. |
| first_indexed | 2025-11-14T19:06:56Z |
| format | Article |
| id | nottingham-29802 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:06:56Z |
| publishDate | 2014 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-298022020-05-04T16:52:24Z https://eprints.nottingham.ac.uk/29802/ A mathematical model of the human metabolic system and metabolic flexibility Pearson, Taliesin Wattis, Jonathan A.D. King, John. R. MacDonald, Ian A. Mazzatti, Dawn In healthy subjects some tissues in the human body display metabolic flexibility, by this we mean the ability for the tissue to switch its fuel source between predominantly carbohydrates in the post prandial state and predominantly fats in the fasted state. Many of the pathways involved with human metabolism are controlled by insulin, and insulin- resistant states such as obesity and type-2 diabetes are characterised by a loss or impairment of metabolic flexibility. In this paper we derive a system of 12 first-order coupled differential equations that describe the transport between and storage in different tissues of the human body. We find steady state solutions to these equations and use these results to nondimensionalise the model. We then solve the model numerically to simulate a healthy balanced meal and a high fat meal and we discuss and compare these results. Our numerical results show good agreement with experimental data where we have data available to us and the results show behaviour that agrees with intuition where we currently have no data with which to compare. Springer 2014-08-15 Article PeerReviewed Pearson, Taliesin, Wattis, Jonathan A.D., King, John. R., MacDonald, Ian A. and Mazzatti, Dawn (2014) A mathematical model of the human metabolic system and metabolic flexibility. Bulletin of Mathematical Biology, 76 (9). pp. 2091-2121. ISSN 0092-8240 Multicompartmental Modelling Insulin Glucose Free Fatty Acids Triglyceride http://link.springer.com/article/10.1007/s11538-014-0001-4 doi:10.1007/s11538-014-0001-4 doi:10.1007/s11538-014-0001-4 |
| spellingShingle | Multicompartmental Modelling Insulin Glucose Free Fatty Acids Triglyceride Pearson, Taliesin Wattis, Jonathan A.D. King, John. R. MacDonald, Ian A. Mazzatti, Dawn A mathematical model of the human metabolic system and metabolic flexibility |
| title | A mathematical model of the human metabolic system and metabolic flexibility |
| title_full | A mathematical model of the human metabolic system and metabolic flexibility |
| title_fullStr | A mathematical model of the human metabolic system and metabolic flexibility |
| title_full_unstemmed | A mathematical model of the human metabolic system and metabolic flexibility |
| title_short | A mathematical model of the human metabolic system and metabolic flexibility |
| title_sort | mathematical model of the human metabolic system and metabolic flexibility |
| topic | Multicompartmental Modelling Insulin Glucose Free Fatty Acids Triglyceride |
| url | https://eprints.nottingham.ac.uk/29802/ https://eprints.nottingham.ac.uk/29802/ https://eprints.nottingham.ac.uk/29802/ |