Exposure to bisphosphonates and risk of cancer: a protocol for nested caseecontrol studies using the QResearch primary care database
Introduction: Bisphosphonates are becoming a common treatment for osteoporosis particularly after discovery of the association between hormone replacement therapy and increased risk of breast cancer. As osteoporosis develops with age, treatment is a long-term intervention. Randomised control tr...
| Main Authors: | , , |
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| Format: | Article |
| Published: |
BMJ Publishing Group
2012
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| Online Access: | https://eprints.nottingham.ac.uk/2980/ |
| _version_ | 1848790923139350528 |
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| author | Vinogradova, Yana Coupland, Carol Hippisley-Cox, Julia |
| author_facet | Vinogradova, Yana Coupland, Carol Hippisley-Cox, Julia |
| author_sort | Vinogradova, Yana |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Introduction: Bisphosphonates are becoming
a common treatment for osteoporosis particularly after
discovery of the association between hormone
replacement therapy and increased risk of breast
cancer. As osteoporosis develops with age, treatment
is a long-term intervention. Randomised control trials
typically have limited follow-up times, which restricts
investigation of the effects of the drugs on risk of
primary cancers. A few observational studies have
demonstrated a reduced risk of breast cancer and
possibly of endometrial cancer in bisphosphonate
users. Two epidemiological studies have studied the
effect of the drugs on oesophageal cancer but did not
reach any definite conclusions. So far, no effects on
colorectal and stomach cancer have been shown. This
study will investigate the association of
bisphosphonates with risks of the 10 most common
primary cancers.
Methods and analysis: A series of nested
caseecontrol studies will be based on the general
population using records from 660 UK general
practices within the QResearch Database. Cases will be
patients with primary cancers diagnosed between
1996 and 2011. Each case will be matched by age, sex,
practice and calendar year to five controls, who are
alive and registered with the practice at the time of
diagnosis of the case. Exposure to bisphosphonates
will be defined as at least one prescription during the
study period. For the most common cancers with
substantial numbers of observations, the effect of the
duration of the treatment and different types of
bisphosphonates will be studied. Conditional logistic
regression will be applied to produce ORs adjusted for
smoking status, socioeconomic status, ethnicity,
cancer-specific co-morbidities and use of other
medications. |
| first_indexed | 2025-11-14T18:20:19Z |
| format | Article |
| id | nottingham-2980 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:20:19Z |
| publishDate | 2012 |
| publisher | BMJ Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-29802020-05-04T16:32:14Z https://eprints.nottingham.ac.uk/2980/ Exposure to bisphosphonates and risk of cancer: a protocol for nested caseecontrol studies using the QResearch primary care database Vinogradova, Yana Coupland, Carol Hippisley-Cox, Julia Introduction: Bisphosphonates are becoming a common treatment for osteoporosis particularly after discovery of the association between hormone replacement therapy and increased risk of breast cancer. As osteoporosis develops with age, treatment is a long-term intervention. Randomised control trials typically have limited follow-up times, which restricts investigation of the effects of the drugs on risk of primary cancers. A few observational studies have demonstrated a reduced risk of breast cancer and possibly of endometrial cancer in bisphosphonate users. Two epidemiological studies have studied the effect of the drugs on oesophageal cancer but did not reach any definite conclusions. So far, no effects on colorectal and stomach cancer have been shown. This study will investigate the association of bisphosphonates with risks of the 10 most common primary cancers. Methods and analysis: A series of nested caseecontrol studies will be based on the general population using records from 660 UK general practices within the QResearch Database. Cases will be patients with primary cancers diagnosed between 1996 and 2011. Each case will be matched by age, sex, practice and calendar year to five controls, who are alive and registered with the practice at the time of diagnosis of the case. Exposure to bisphosphonates will be defined as at least one prescription during the study period. For the most common cancers with substantial numbers of observations, the effect of the duration of the treatment and different types of bisphosphonates will be studied. Conditional logistic regression will be applied to produce ORs adjusted for smoking status, socioeconomic status, ethnicity, cancer-specific co-morbidities and use of other medications. BMJ Publishing Group 2012-01-12 Article PeerReviewed Vinogradova, Yana, Coupland, Carol and Hippisley-Cox, Julia (2012) Exposure to bisphosphonates and risk of cancer: a protocol for nested caseecontrol studies using the QResearch primary care database. BMJ Open, 2 (1). e000548/1-e000548/6. ISSN 2044-6055 http://bmjopen.bmj.com/content/2/1/e000548 doi:10.1136/bmjopen-2011-000548 doi:10.1136/bmjopen-2011-000548 |
| spellingShingle | Vinogradova, Yana Coupland, Carol Hippisley-Cox, Julia Exposure to bisphosphonates and risk of cancer: a protocol for nested caseecontrol studies using the QResearch primary care database |
| title | Exposure to bisphosphonates and risk of cancer: a protocol for nested caseecontrol studies using the QResearch primary care database |
| title_full | Exposure to bisphosphonates and risk of cancer: a protocol for nested caseecontrol studies using the QResearch primary care database |
| title_fullStr | Exposure to bisphosphonates and risk of cancer: a protocol for nested caseecontrol studies using the QResearch primary care database |
| title_full_unstemmed | Exposure to bisphosphonates and risk of cancer: a protocol for nested caseecontrol studies using the QResearch primary care database |
| title_short | Exposure to bisphosphonates and risk of cancer: a protocol for nested caseecontrol studies using the QResearch primary care database |
| title_sort | exposure to bisphosphonates and risk of cancer: a protocol for nested caseecontrol studies using the qresearch primary care database |
| url | https://eprints.nottingham.ac.uk/2980/ https://eprints.nottingham.ac.uk/2980/ https://eprints.nottingham.ac.uk/2980/ |