Expression of myogenic regulatory factors in chicken embryos during somite and limb development
The expression of the myogenic regulatory factors (MRFs), Myf5, MyoD, myogenin (Mgn) and MRF4 have been analysed during the development of chicken embryo somites and limbs. In somites, Myf5 is expressed first in somites and paraxial mesoderm at HH stage 9 followed by MyoD at HH stage 12, and Mgn and...
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| Format: | Article |
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Wiley
2015
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| Online Access: | https://eprints.nottingham.ac.uk/29763/ |
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| author | Mok, Gi Fay Mohammed, Rabeea Hazim Sweetman, Dylan |
| author_facet | Mok, Gi Fay Mohammed, Rabeea Hazim Sweetman, Dylan |
| author_sort | Mok, Gi Fay |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The expression of the myogenic regulatory factors (MRFs), Myf5, MyoD, myogenin (Mgn) and MRF4 have been analysed during the development of chicken embryo somites and limbs. In somites, Myf5 is expressed first in somites and paraxial mesoderm at HH stage 9 followed by MyoD at HH stage 12, and Mgn and MRF4 at HH stage 14. In older somites, Myf5 and MyoD are also expressed in the ventrally extending myotome prior to Mgn and MRF4 expression. In limb muscles a similar temporal sequence is observed with Myf5 expression detected first in forelimbs at HH stage 22, MyoD at HH stage 23, Mgn at HH stage 24 and MRF4 at HH stage 30. This report describes the precise time of onset of expression of each MRF in somites and limbs during chicken embryo development, and provides a detailed comparative timeline of MRF expression in different embryonic muscle groups. |
| first_indexed | 2025-11-14T19:06:49Z |
| format | Article |
| id | nottingham-29763 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:06:49Z |
| publishDate | 2015 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-297632020-05-04T17:12:56Z https://eprints.nottingham.ac.uk/29763/ Expression of myogenic regulatory factors in chicken embryos during somite and limb development Mok, Gi Fay Mohammed, Rabeea Hazim Sweetman, Dylan The expression of the myogenic regulatory factors (MRFs), Myf5, MyoD, myogenin (Mgn) and MRF4 have been analysed during the development of chicken embryo somites and limbs. In somites, Myf5 is expressed first in somites and paraxial mesoderm at HH stage 9 followed by MyoD at HH stage 12, and Mgn and MRF4 at HH stage 14. In older somites, Myf5 and MyoD are also expressed in the ventrally extending myotome prior to Mgn and MRF4 expression. In limb muscles a similar temporal sequence is observed with Myf5 expression detected first in forelimbs at HH stage 22, MyoD at HH stage 23, Mgn at HH stage 24 and MRF4 at HH stage 30. This report describes the precise time of onset of expression of each MRF in somites and limbs during chicken embryo development, and provides a detailed comparative timeline of MRF expression in different embryonic muscle groups. Wiley 2015-07-16 Article PeerReviewed Mok, Gi Fay, Mohammed, Rabeea Hazim and Sweetman, Dylan (2015) Expression of myogenic regulatory factors in chicken embryos during somite and limb development. Journal of Anatomy, 227 (3). pp. 352-360. ISSN 1469-7580 Chicken embryo MRF MRF4 Myf5 MyoD Myogenesis Myogenin http://onlinelibrary.wiley.com/doi/10.1111/joa.12340/abstract doi:10.1111/joa.12340 doi:10.1111/joa.12340 |
| spellingShingle | Chicken embryo MRF MRF4 Myf5 MyoD Myogenesis Myogenin Mok, Gi Fay Mohammed, Rabeea Hazim Sweetman, Dylan Expression of myogenic regulatory factors in chicken embryos during somite and limb development |
| title | Expression of myogenic regulatory factors in chicken embryos during somite and limb development |
| title_full | Expression of myogenic regulatory factors in chicken embryos during somite and limb development |
| title_fullStr | Expression of myogenic regulatory factors in chicken embryos during somite and limb development |
| title_full_unstemmed | Expression of myogenic regulatory factors in chicken embryos during somite and limb development |
| title_short | Expression of myogenic regulatory factors in chicken embryos during somite and limb development |
| title_sort | expression of myogenic regulatory factors in chicken embryos during somite and limb development |
| topic | Chicken embryo MRF MRF4 Myf5 MyoD Myogenesis Myogenin |
| url | https://eprints.nottingham.ac.uk/29763/ https://eprints.nottingham.ac.uk/29763/ https://eprints.nottingham.ac.uk/29763/ |