Evaluation of transcriptional cyclin dependent kinase inhibitors as potential cancer therapeutics

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Evaluation of transcriptional cyclin dependent kinase inhibitors as potential cancer therapeutics

Cancer cells depend heavily on sustained expression of anti-apoptotic proteins. Targeting transcription to suppress these anti-apoptotic proteins seems a promising strategy for anti-cancer therapy. Cyclin-dependant kinase 9 (CDK9) regulates transcription elongation by phosphorylating Ser2 on the C-t...

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Bibliographic Details
Main Author:	Liu, Xiangrui
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2012
Subjects:	cancer cells anti-apoptotic proteins cyclin-dependent kinases
Online Access:	https://eprints.nottingham.ac.uk/29653/

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