Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: role of the prelimbic cortex
Previous studies have shown that dopamine D1 receptor antagonists impair novel object recognition memory but the effects of dopamine D1 receptor stimulation remain to be determined. This study investigated the effects of the selective dopamine D1 receptor agonist SKF81297 on acquisition and retrieva...
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| Format: | Article |
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Elsevier
2015
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| Online Access: | https://eprints.nottingham.ac.uk/29560/ |
| _version_ | 1848793810789728256 |
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| author | Pezze, Marie A. Marshall, Hayley J. Fone, Kevin C.F. Cassaday, Helen J. |
| author_facet | Pezze, Marie A. Marshall, Hayley J. Fone, Kevin C.F. Cassaday, Helen J. |
| author_sort | Pezze, Marie A. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Previous studies have shown that dopamine D1 receptor antagonists impair novel object recognition memory but the effects of dopamine D1 receptor stimulation remain to be determined. This study investigated the effects of the selective dopamine D1 receptor agonist SKF81297 on acquisition and retrieval in the novel object recognition task in male Wistar rats. SKF81297 (0.4 and 0.8mg/kg s.c.) given 15 min before the sampling phase impaired novel object recognition evaluated 10 min or 24h later. The same treatments also reduced novel object recognition memory tested 24h after the sampling phase and when given 15min before the choice session. These data indicate that D1 receptor stimulation modulates both the encoding and retrieval of object recognition memory. Microinfusion of SKF81297 (0.025 or 0.05 μg/side) into the prelimbic sub-region of the medial prefrontal cortex (mPFC) in this case 10 min before the sampling phase also impaired novel object recognition memory, suggesting that the mPFC is one important site mediating the effects of D1 receptor stimulation on visual recognition memory. |
| first_indexed | 2025-11-14T19:06:13Z |
| format | Article |
| id | nottingham-29560 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:06:13Z |
| publishDate | 2015 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-295602020-05-04T17:12:04Z https://eprints.nottingham.ac.uk/29560/ Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: role of the prelimbic cortex Pezze, Marie A. Marshall, Hayley J. Fone, Kevin C.F. Cassaday, Helen J. Previous studies have shown that dopamine D1 receptor antagonists impair novel object recognition memory but the effects of dopamine D1 receptor stimulation remain to be determined. This study investigated the effects of the selective dopamine D1 receptor agonist SKF81297 on acquisition and retrieval in the novel object recognition task in male Wistar rats. SKF81297 (0.4 and 0.8mg/kg s.c.) given 15 min before the sampling phase impaired novel object recognition evaluated 10 min or 24h later. The same treatments also reduced novel object recognition memory tested 24h after the sampling phase and when given 15min before the choice session. These data indicate that D1 receptor stimulation modulates both the encoding and retrieval of object recognition memory. Microinfusion of SKF81297 (0.025 or 0.05 μg/side) into the prelimbic sub-region of the medial prefrontal cortex (mPFC) in this case 10 min before the sampling phase also impaired novel object recognition memory, suggesting that the mPFC is one important site mediating the effects of D1 receptor stimulation on visual recognition memory. Elsevier 2015-07-31 Article PeerReviewed Pezze, Marie A., Marshall, Hayley J., Fone, Kevin C.F. and Cassaday, Helen J. (2015) Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: role of the prelimbic cortex. European Neuropsychopharmacology . ISSN 0924-977X D1 receptors SK81297 Novel object recognition Medial prefrontal cortex Rat http://www.sciencedirect.com/science/article/pii/S0924977X15002369 doi:10.1016/j.euroneuro.2015.07.018 doi:10.1016/j.euroneuro.2015.07.018 |
| spellingShingle | D1 receptors SK81297 Novel object recognition Medial prefrontal cortex Rat Pezze, Marie A. Marshall, Hayley J. Fone, Kevin C.F. Cassaday, Helen J. Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: role of the prelimbic cortex |
| title | Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: role of the prelimbic cortex |
| title_full | Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: role of the prelimbic cortex |
| title_fullStr | Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: role of the prelimbic cortex |
| title_full_unstemmed | Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: role of the prelimbic cortex |
| title_short | Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: role of the prelimbic cortex |
| title_sort | dopamine d1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: role of the prelimbic cortex |
| topic | D1 receptors SK81297 Novel object recognition Medial prefrontal cortex Rat |
| url | https://eprints.nottingham.ac.uk/29560/ https://eprints.nottingham.ac.uk/29560/ https://eprints.nottingham.ac.uk/29560/ |