Structure activity relationships of αv integrin antagonists for pulmonary fibrosis by variation in aryl substituents

Structure activity relationships of αv integrin antagonists for pulmonary fibrosis by variation in aryl substituents

Antagonism of alphav beta6 is emerging as a potential treatment of idiopathic pulmonary fibrosis based on strong target validation. Starting from an alphav beta3 antagonist lead and through simple variation in the nature and position of aryl substituent, the discovery of compounds with improved alp...

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Main Authors: Adams, James, Anderson, Edward C., Blackham, Emma E., Chiu, Yin Wa Ryan, Clarke, Thomas, Eccles, Natasha, Gill, Luke A., Haye, Joshua J., Haywood, Harvey T., Hoenig, Christian R., Russell, Hannah L., Smedley, Christopher, Tipping, William J., Tongue, Tom, Wood, Charlotte C., Yeung, Jason, Rowedder, James E., Fray, Michael J., Mcinally, Thomas, Macdonald, Simon J.F.
Format: Article
Published: American Chemical Society 2014
Subjects:
integrins
antagonist
pulmonary
fibrosis
αvβ6
αvβ3
β-amino acids
Online Access:https://eprints.nottingham.ac.uk/29558/

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