Novel function for the p38-MK2 signaling pathway in circulating CD1c+ (BDCA-1+) myeloid dendritic cells from healthy donors and advanced cancer patients; inhibition of p38 enhances IL-12 whilst suppressing IL-10

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Novel function for the p38-MK2 signaling pathway in circulating CD1c+ (BDCA-1+) myeloid dendritic cells from healthy donors and advanced cancer patients; inhibition of p38 enhances IL-12 whilst suppressing IL-10

There is growing interest in myeloid (my) dendritic cells (DC) as an alternative to monocyte-derived DC (moDC) for immunotherapy. However, in contrast to moDC, little is known regarding the effect of malignancy on the function, abundance or use of intracellular signaling pathways in myDC. Understand...

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Bibliographic Details
Main Authors:	Franks, Hester A., Wang, Qunwei, Lax, Stephanie J., Colllins, Mary K., Escors, David, Patel, Poulam M., Jackson, Andrew M.
Format:	Article
Published:	Wiley 2014
Online Access:	https://eprints.nottingham.ac.uk/2954/

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