Targeting Ataxia telangiectasia mutated (ATM) and DNA dependent protein kinase catalytic subunit (DNA-PKcs) for synthetic lethality application in breast cancer

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Targeting Ataxia telangiectasia mutated (ATM) and DNA dependent protein kinase catalytic subunit (DNA-PKcs) for synthetic lethality application in breast cancer

BRCA1 germ-line mutations predispose to hereditary breast and ovarian cancers. Cells lacking functional BRCA1 protein are deficient in the homologous recombination DNA repair pathway. Base excision repair (BER) is essential for processing base damage induced by endogenous and exogenous sources. Rece...

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Bibliographic Details
Main Author:	Albarakati, Nada
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2015
Subjects:	ATM; BRCA1; Base excision repair; Cisplatin; DNA-PKcs; Small molecule inhibitors; Synthetic lethality
Online Access:	https://eprints.nottingham.ac.uk/29408/

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