The acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study
Background: No studies have investigated the immediate impact of receiving an allogeneic hematopoietic stem cell transplant (HSCT) on pulmonary inflammation or lung function. Methods: Using a prospective study design, we quantified the changes in these outcome measures in eligible adult individu...
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| Format: | Article |
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BioMed Central
2013
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| Online Access: | https://eprints.nottingham.ac.uk/2934/ |
| _version_ | 1848790912296026112 |
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| author | Enocson, Alexandra Hubbard, Richard McKeever, Tricia M. Russell, Nigel Byrne, Jennifer Das-Gupta, Emma Watson, Lynne Fogarty, Andrew W. |
| author_facet | Enocson, Alexandra Hubbard, Richard McKeever, Tricia M. Russell, Nigel Byrne, Jennifer Das-Gupta, Emma Watson, Lynne Fogarty, Andrew W. |
| author_sort | Enocson, Alexandra |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background: No studies have investigated the immediate impact of receiving an allogeneic hematopoietic stem cell transplant (HSCT) on pulmonary inflammation or lung function.
Methods: Using a prospective study design, we quantified the changes in these outcome measures in eligible adult individuals in the first six months after receiving an allogeneic hematopoietic stem cell transplant.
Results: Between January 2007 and December 2008, 72 patients were eligible to participate in the cohort, and of these 68 (94%) were included in the study. Compared to baseline, pulmonary inflammation as measured by exhaled nitric oxide increased after receiving a HSCT with the largest increment seen at three months (+6.0ppb, 95%CI: +0.4 to +11.5), and this was sustained at six months. Percent predicted forced expiratory volume in one second decreased over the same period, with the largest decrease observed at six weeks (−5.9%, 95% CI: -8.9 to −2.9), and this was also sustained over a six month period. Similar associations were observed for FVC. A larger increase in exhaled nitric oxide from baseline at six weeks and three months may be associated with decreased mortality (p=0.06, p=0.04 respectively).
Conclusion: Our data demonstrate that recipients of an allogeneic HSCT experience an increase in biomarkers of pulmonary inflammation and a decrease in lung function in the first six months after the procedure. If independently validated in other study populations, these observations could have potential as a prognostic biomarker for this patient group. |
| first_indexed | 2025-11-14T18:20:09Z |
| format | Article |
| id | nottingham-2934 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:20:09Z |
| publishDate | 2013 |
| publisher | BioMed Central |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-29342020-05-04T16:35:31Z https://eprints.nottingham.ac.uk/2934/ The acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study Enocson, Alexandra Hubbard, Richard McKeever, Tricia M. Russell, Nigel Byrne, Jennifer Das-Gupta, Emma Watson, Lynne Fogarty, Andrew W. Background: No studies have investigated the immediate impact of receiving an allogeneic hematopoietic stem cell transplant (HSCT) on pulmonary inflammation or lung function. Methods: Using a prospective study design, we quantified the changes in these outcome measures in eligible adult individuals in the first six months after receiving an allogeneic hematopoietic stem cell transplant. Results: Between January 2007 and December 2008, 72 patients were eligible to participate in the cohort, and of these 68 (94%) were included in the study. Compared to baseline, pulmonary inflammation as measured by exhaled nitric oxide increased after receiving a HSCT with the largest increment seen at three months (+6.0ppb, 95%CI: +0.4 to +11.5), and this was sustained at six months. Percent predicted forced expiratory volume in one second decreased over the same period, with the largest decrease observed at six weeks (−5.9%, 95% CI: -8.9 to −2.9), and this was also sustained over a six month period. Similar associations were observed for FVC. A larger increase in exhaled nitric oxide from baseline at six weeks and three months may be associated with decreased mortality (p=0.06, p=0.04 respectively). Conclusion: Our data demonstrate that recipients of an allogeneic HSCT experience an increase in biomarkers of pulmonary inflammation and a decrease in lung function in the first six months after the procedure. If independently validated in other study populations, these observations could have potential as a prognostic biomarker for this patient group. BioMed Central 2013-01-11 Article PeerReviewed Enocson, Alexandra, Hubbard, Richard, McKeever, Tricia M., Russell, Nigel, Byrne, Jennifer, Das-Gupta, Emma, Watson, Lynne and Fogarty, Andrew W. (2013) The acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study. BMC Pulmonary Medicine, 13 (Januar). 6/1-6/6. ISSN 1471-2466 Lung function Inflammation Haematopoietic transplant http://www.biomedcentral.com/1471-2466/13/2 doi:10.1186/1471-2466-13-2 doi:10.1186/1471-2466-13-2 |
| spellingShingle | Lung function Inflammation Haematopoietic transplant Enocson, Alexandra Hubbard, Richard McKeever, Tricia M. Russell, Nigel Byrne, Jennifer Das-Gupta, Emma Watson, Lynne Fogarty, Andrew W. The acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study |
| title | The acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study |
| title_full | The acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study |
| title_fullStr | The acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study |
| title_full_unstemmed | The acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study |
| title_short | The acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study |
| title_sort | acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study |
| topic | Lung function Inflammation Haematopoietic transplant |
| url | https://eprints.nottingham.ac.uk/2934/ https://eprints.nottingham.ac.uk/2934/ https://eprints.nottingham.ac.uk/2934/ |