Dynamic recruitment of resting state sub-networks
Resting state networks (RSNs) are of fundamental importance in human systems neuroscience with evidence suggesting that they are integral to healthy brain function and perturbed in pathology. Despite rapid progress in this area, the temporal dynamics governing the functional connectivities that unde...
| Main Authors: | , , , , , |
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| Format: | Article |
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Elsevier
2015
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| Online Access: | https://eprints.nottingham.ac.uk/29300/ |
| _version_ | 1848793757345906688 |
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| author | O'Neill, George C. Bauer, Markus Woolrich, Mark W. Morris, Peter G. Barnes, Gareth R. Brookes, Matthew Jon |
| author_facet | O'Neill, George C. Bauer, Markus Woolrich, Mark W. Morris, Peter G. Barnes, Gareth R. Brookes, Matthew Jon |
| author_sort | O'Neill, George C. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Resting state networks (RSNs) are of fundamental importance in human systems neuroscience with evidence suggesting that they are integral to healthy brain function and perturbed in pathology. Despite rapid progress in this area, the temporal dynamics governing the functional connectivities that underlie RSN structure remain poorly understood. Here, we present a framework to help further our understanding of RSN dynamics. We describe a methodology which exploits the direct nature and high temporal resolution of magnetoencephalography (MEG). This technique, which builds on previous work, extends from solving fundamental confounds in MEG (source leakage) to multivariate modelling of transient connectivity. The resulting processing pipeline facilitates direct (electrophysiological) measurement of dynamic functional networks. Our results show that, when functional connectivity is assessed in small time windows, the canonical sensorimotor network can be decomposed into a number of transiently synchronising sub-networks, recruitment of which depends on current mental state. These rapidly changing sub-networks are spatially focal with, for example, bilateral primary sensory and motor areas resolved into two separate sub-networks. The likely interpretation is that the larger canonical sensorimotor network most often seen in neuroimaging studies reflects only a temporal aggregate of these transient sub-networks. Our approach opens new frontiers to study RSN dynamics, showing that MEG is capable of revealing the spatial, temporal and spectral signature of the human connectome in health and disease. |
| first_indexed | 2025-11-14T19:05:22Z |
| format | Article |
| id | nottingham-29300 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:05:22Z |
| publishDate | 2015 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-293002020-05-04T17:13:03Z https://eprints.nottingham.ac.uk/29300/ Dynamic recruitment of resting state sub-networks O'Neill, George C. Bauer, Markus Woolrich, Mark W. Morris, Peter G. Barnes, Gareth R. Brookes, Matthew Jon Resting state networks (RSNs) are of fundamental importance in human systems neuroscience with evidence suggesting that they are integral to healthy brain function and perturbed in pathology. Despite rapid progress in this area, the temporal dynamics governing the functional connectivities that underlie RSN structure remain poorly understood. Here, we present a framework to help further our understanding of RSN dynamics. We describe a methodology which exploits the direct nature and high temporal resolution of magnetoencephalography (MEG). This technique, which builds on previous work, extends from solving fundamental confounds in MEG (source leakage) to multivariate modelling of transient connectivity. The resulting processing pipeline facilitates direct (electrophysiological) measurement of dynamic functional networks. Our results show that, when functional connectivity is assessed in small time windows, the canonical sensorimotor network can be decomposed into a number of transiently synchronising sub-networks, recruitment of which depends on current mental state. These rapidly changing sub-networks are spatially focal with, for example, bilateral primary sensory and motor areas resolved into two separate sub-networks. The likely interpretation is that the larger canonical sensorimotor network most often seen in neuroimaging studies reflects only a temporal aggregate of these transient sub-networks. Our approach opens new frontiers to study RSN dynamics, showing that MEG is capable of revealing the spatial, temporal and spectral signature of the human connectome in health and disease. Elsevier 2015-07-15 Article PeerReviewed O'Neill, George C., Bauer, Markus, Woolrich, Mark W., Morris, Peter G., Barnes, Gareth R. and Brookes, Matthew Jon (2015) Dynamic recruitment of resting state sub-networks. NeuroImage, 115 . pp. 85-95. ISSN 1053-8119 http://www.sciencedirect.com/science/article/pii/S1053811915003213 doi:10.1016/j.neuroimage.2015.04.030 doi:10.1016/j.neuroimage.2015.04.030 |
| spellingShingle | O'Neill, George C. Bauer, Markus Woolrich, Mark W. Morris, Peter G. Barnes, Gareth R. Brookes, Matthew Jon Dynamic recruitment of resting state sub-networks |
| title | Dynamic recruitment of resting state sub-networks |
| title_full | Dynamic recruitment of resting state sub-networks |
| title_fullStr | Dynamic recruitment of resting state sub-networks |
| title_full_unstemmed | Dynamic recruitment of resting state sub-networks |
| title_short | Dynamic recruitment of resting state sub-networks |
| title_sort | dynamic recruitment of resting state sub-networks |
| url | https://eprints.nottingham.ac.uk/29300/ https://eprints.nottingham.ac.uk/29300/ https://eprints.nottingham.ac.uk/29300/ |