SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ

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SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ

The biologic effects of IFNγ are mediated by the transcription factor STAT1. The activity of STAT1 is inhibited by small ubiquitin-like modifier (SUMO) conjugation. This occurs both directly through decreasing STAT1 tyrosine phosphorylation and indirectly by facilitating STAT1 dephosphorylation cons...

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Bibliographic Details
Main Authors:	Begitt, Andreas, Droescher, Mathias, Knobeloch, Klaus-Peter, Vinkemeier, Uwe
Format:	Article
Published:	American Society for Hematology 2011
Online Access:	https://eprints.nottingham.ac.uk/2930/

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