Evolution of equine influenza virus in vaccinated horses
Influenza A viruses are characterized by their ability to evade host immunity, even in vaccinated individuals. To determine how prior immunity shapes viral diversity in vivo, we studied the intra- and interhost evolution of equine influenza virus in vaccinated horses. Although the level and structur...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
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American Society for Microbiology
2013
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| Online Access: | https://eprints.nottingham.ac.uk/29218/ |
| _version_ | 1848793740105220096 |
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| author | Murcia, Pablo R. Baillie, Gregory J. Stack, J. Conrad Jervis, Carley Elton, Debra Mumford, Jennifer A. Daly, Janet M. Kellam, Paul Grenfell, Bryan T. Holmes, Edward C. Wood, James L.N. |
| author_facet | Murcia, Pablo R. Baillie, Gregory J. Stack, J. Conrad Jervis, Carley Elton, Debra Mumford, Jennifer A. Daly, Janet M. Kellam, Paul Grenfell, Bryan T. Holmes, Edward C. Wood, James L.N. |
| author_sort | Murcia, Pablo R. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Influenza A viruses are characterized by their ability to evade host immunity, even in vaccinated individuals. To determine how prior immunity shapes viral diversity in vivo, we studied the intra- and interhost evolution of equine influenza virus in vaccinated horses. Although the level and structure of genetic diversity were similar to those in naive horses, intrahost bottlenecks may be more stringent in vaccinated animals, and mutations shared among horses often fall close to putative antigenic sites. |
| first_indexed | 2025-11-14T19:05:06Z |
| format | Article |
| id | nottingham-29218 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:05:06Z |
| publishDate | 2013 |
| publisher | American Society for Microbiology |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-292182020-05-04T16:35:55Z https://eprints.nottingham.ac.uk/29218/ Evolution of equine influenza virus in vaccinated horses Murcia, Pablo R. Baillie, Gregory J. Stack, J. Conrad Jervis, Carley Elton, Debra Mumford, Jennifer A. Daly, Janet M. Kellam, Paul Grenfell, Bryan T. Holmes, Edward C. Wood, James L.N. Influenza A viruses are characterized by their ability to evade host immunity, even in vaccinated individuals. To determine how prior immunity shapes viral diversity in vivo, we studied the intra- and interhost evolution of equine influenza virus in vaccinated horses. Although the level and structure of genetic diversity were similar to those in naive horses, intrahost bottlenecks may be more stringent in vaccinated animals, and mutations shared among horses often fall close to putative antigenic sites. American Society for Microbiology 2013-04-01 Article PeerReviewed Murcia, Pablo R., Baillie, Gregory J., Stack, J. Conrad, Jervis, Carley, Elton, Debra, Mumford, Jennifer A., Daly, Janet M., Kellam, Paul, Grenfell, Bryan T., Holmes, Edward C. and Wood, James L.N. (2013) Evolution of equine influenza virus in vaccinated horses. Journal of Virology, 87 (8). pp. 4768-4771. ISSN 0022-538X horses equine influenza vaccines vaccination pathogens http://jvi.asm.org/content/87/8/4768.full doi:10.1128/JVI.03379-12 doi:10.1128/JVI.03379-12 |
| spellingShingle | horses equine influenza vaccines vaccination pathogens Murcia, Pablo R. Baillie, Gregory J. Stack, J. Conrad Jervis, Carley Elton, Debra Mumford, Jennifer A. Daly, Janet M. Kellam, Paul Grenfell, Bryan T. Holmes, Edward C. Wood, James L.N. Evolution of equine influenza virus in vaccinated horses |
| title | Evolution of equine influenza virus in vaccinated horses |
| title_full | Evolution of equine influenza virus in vaccinated horses |
| title_fullStr | Evolution of equine influenza virus in vaccinated horses |
| title_full_unstemmed | Evolution of equine influenza virus in vaccinated horses |
| title_short | Evolution of equine influenza virus in vaccinated horses |
| title_sort | evolution of equine influenza virus in vaccinated horses |
| topic | horses equine influenza vaccines vaccination pathogens |
| url | https://eprints.nottingham.ac.uk/29218/ https://eprints.nottingham.ac.uk/29218/ https://eprints.nottingham.ac.uk/29218/ |