Modelling angiogenesis in three dimensions
The process through which new blood vessels are formed within the body is known as angiogenesis. An essential part of our survival, it has also been implicated more recently in many diseases both in terms of induced growth, and abnormal vascular structure. Angiogenesis is characterized as two pro...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
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2015
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| Online Access: | https://eprints.nottingham.ac.uk/29075/ |
| _version_ | 1848793709948174336 |
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| author | Parsonson, Louis |
| author_facet | Parsonson, Louis |
| author_sort | Parsonson, Louis |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The process through which new blood vessels are formed within the body is known as angiogenesis. An essential part of our survival, it has also been implicated more recently in many diseases both in terms of induced growth, and abnormal vascular structure.
Angiogenesis is characterized as two processes, the development of a vascular network during embryonic growth and the production of new blood vessels. This work focuses on the latter, and seeks to develop a robust, three-dimensional model for simulating blood vessel growth and the attendant processes of blood flow and mass transfer within the simulated system. A system was developed which utilises medical imaging scan data (specifically, MicroCT) as the initial conditions from which a network of vessels is grown. This is combined with GPU accelerated simulations of fluid dynamics, with the intention of providing a technique for future use in predictive medicine and therapeutic simulation. |
| first_indexed | 2025-11-14T19:04:37Z |
| format | Thesis (University of Nottingham only) |
| id | nottingham-29075 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T19:04:37Z |
| publishDate | 2015 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-290752025-02-28T11:35:18Z https://eprints.nottingham.ac.uk/29075/ Modelling angiogenesis in three dimensions Parsonson, Louis The process through which new blood vessels are formed within the body is known as angiogenesis. An essential part of our survival, it has also been implicated more recently in many diseases both in terms of induced growth, and abnormal vascular structure. Angiogenesis is characterized as two processes, the development of a vascular network during embryonic growth and the production of new blood vessels. This work focuses on the latter, and seeks to develop a robust, three-dimensional model for simulating blood vessel growth and the attendant processes of blood flow and mass transfer within the simulated system. A system was developed which utilises medical imaging scan data (specifically, MicroCT) as the initial conditions from which a network of vessels is grown. This is combined with GPU accelerated simulations of fluid dynamics, with the intention of providing a technique for future use in predictive medicine and therapeutic simulation. 2015-07-07 Thesis (University of Nottingham only) NonPeerReviewed application/pdf en arr https://eprints.nottingham.ac.uk/29075/2/Modelling%20Angiogenesis%20in%20Three%20Dimensions.pdf Parsonson, Louis (2015) Modelling angiogenesis in three dimensions. PhD thesis, University of Nottingham. Angiogenesis simulation three dimensions fluid dynamics blood flow diffusion |
| spellingShingle | Angiogenesis simulation three dimensions fluid dynamics blood flow diffusion Parsonson, Louis Modelling angiogenesis in three dimensions |
| title | Modelling angiogenesis in three dimensions |
| title_full | Modelling angiogenesis in three dimensions |
| title_fullStr | Modelling angiogenesis in three dimensions |
| title_full_unstemmed | Modelling angiogenesis in three dimensions |
| title_short | Modelling angiogenesis in three dimensions |
| title_sort | modelling angiogenesis in three dimensions |
| topic | Angiogenesis simulation three dimensions fluid dynamics blood flow diffusion |
| url | https://eprints.nottingham.ac.uk/29075/ |