The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module

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The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module

In eukaryotic cells, the shortening and removal of the poly(A) tail (deadenylation) of cytoplasmic mRNA is a key event in regulated mRNA degradation. A major enzyme involved in deadenylation is the Ccr4-Not deadenylase complex, which can be recruited to its target mRNA by RNA-binding proteins or the...

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Bibliographic Details
Main Authors:	Maryati, Marayti, Airhihen, Blessing, Winkler, G. Sebastiaan
Format:	Article
Published:	Portland Press 2015
Subjects:	Ccr4-Not; ribonuclease; poly(A); deadenylase; mRNA decay; post-transcriptional gene regulation
Online Access:	https://eprints.nottingham.ac.uk/28955/

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