Mathematical modelling of hepatic lipid metabolism
The aim of this paper is to develop a mathematical model capable of simulating the metabolic response to a variety of mixed meals in fed and fasted conditions with particular emphasis placed on the hepatic triglyceride element of the model. Model validation is carried out using experimental data fo...
| Main Authors: | , , |
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| Format: | Article |
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Elsevier
2015
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| Online Access: | https://eprints.nottingham.ac.uk/28924/ |
| _version_ | 1848793675083022336 |
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| author | Pratt, Adrian C. Wattis, Jonathan A.D. Salter, Andrew M. |
| author_facet | Pratt, Adrian C. Wattis, Jonathan A.D. Salter, Andrew M. |
| author_sort | Pratt, Adrian C. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The aim of this paper is to develop a mathematical model capable of simulating the metabolic response to a variety of mixed meals in fed and fasted conditions with particular emphasis placed on the hepatic triglyceride element of the model. Model validation is carried out using experimental data for the ingestion of three mixed composition meals over a 24-hour period. Comparison with experimental data suggests the model predicts key plasma lipids accurately given a prescribed insulin profile. One counter-intuitive observation to arise from simulations is that liver triglyceride initially decreases when a high fat meal is ingested, a phenomenon potentially explained by the carbohydrate portion of the meal raising plasma insulin. |
| first_indexed | 2025-11-14T19:04:04Z |
| format | Article |
| id | nottingham-28924 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:04:04Z |
| publishDate | 2015 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-289242020-05-04T20:09:19Z https://eprints.nottingham.ac.uk/28924/ Mathematical modelling of hepatic lipid metabolism Pratt, Adrian C. Wattis, Jonathan A.D. Salter, Andrew M. The aim of this paper is to develop a mathematical model capable of simulating the metabolic response to a variety of mixed meals in fed and fasted conditions with particular emphasis placed on the hepatic triglyceride element of the model. Model validation is carried out using experimental data for the ingestion of three mixed composition meals over a 24-hour period. Comparison with experimental data suggests the model predicts key plasma lipids accurately given a prescribed insulin profile. One counter-intuitive observation to arise from simulations is that liver triglyceride initially decreases when a high fat meal is ingested, a phenomenon potentially explained by the carbohydrate portion of the meal raising plasma insulin. Elsevier 2015-04 Article PeerReviewed Pratt, Adrian C., Wattis, Jonathan A.D. and Salter, Andrew M. (2015) Mathematical modelling of hepatic lipid metabolism. Mathematical Biosciences, 262 . pp. 167-181. ISSN 0025-5564 http://www.sciencedirect.com/science/article/pii/S0025556415000188 doi:10.1016/j.mbs.2014.12.012 doi:10.1016/j.mbs.2014.12.012 |
| spellingShingle | Pratt, Adrian C. Wattis, Jonathan A.D. Salter, Andrew M. Mathematical modelling of hepatic lipid metabolism |
| title | Mathematical modelling of hepatic lipid metabolism |
| title_full | Mathematical modelling of hepatic lipid metabolism |
| title_fullStr | Mathematical modelling of hepatic lipid metabolism |
| title_full_unstemmed | Mathematical modelling of hepatic lipid metabolism |
| title_short | Mathematical modelling of hepatic lipid metabolism |
| title_sort | mathematical modelling of hepatic lipid metabolism |
| url | https://eprints.nottingham.ac.uk/28924/ https://eprints.nottingham.ac.uk/28924/ https://eprints.nottingham.ac.uk/28924/ |