First passage times in integrate-and-fire neurons with stochastic thresholds
We consider a leaky integrate--and--fire neuron with deterministic subthreshold dynamics and a firing threshold that evolves as an Ornstein-Uhlenbeck process. The formulation of this minimal model is motivated by the experimentally observed widespread variation of neural firing thresholds. We show n...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Published: |
American Physical Society
2015
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/28677/ |
| _version_ | 1848793622148808704 |
|---|---|
| author | Braun, Wilhelm Matthews, Paul C. Thul, Ruediger |
| author_facet | Braun, Wilhelm Matthews, Paul C. Thul, Ruediger |
| author_sort | Braun, Wilhelm |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | We consider a leaky integrate--and--fire neuron with deterministic subthreshold dynamics and a firing threshold that evolves as an Ornstein-Uhlenbeck process. The formulation of this minimal model is motivated by the experimentally observed widespread variation of neural firing thresholds. We show numerically that the mean first passage time can depend non-monotonically on the noise amplitude. For sufficiently large values of the correlation time of the stochastic threshold the mean first passage time is maximal for non-vanishing noise. We provide an explanation for this effect by analytically transforming the original model into a first passage time problem for Brownian motion. This transformation also allows for a perturbative calculation of the first passage time histograms. In turn this provides quantitative insights into the mechanisms that lead to the non-monotonic behaviour of the mean first passage time. The perturbation expansion is in excellent agreement with direct numerical simulations. The approach developed here can be applied to any deterministic subthreshold dynamics and any Gauss-Markov processes for the firing threshold. This opens up the possibility to incorporate biophysically detailed components into the subthreshold dynamics, rendering our approach a powerful framework that sits between traditional integrate-and-fire models and complex mechanistic descriptions of neural dynamics. |
| first_indexed | 2025-11-14T19:03:13Z |
| format | Article |
| id | nottingham-28677 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:03:13Z |
| publishDate | 2015 |
| publisher | American Physical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-286772020-05-04T17:08:46Z https://eprints.nottingham.ac.uk/28677/ First passage times in integrate-and-fire neurons with stochastic thresholds Braun, Wilhelm Matthews, Paul C. Thul, Ruediger We consider a leaky integrate--and--fire neuron with deterministic subthreshold dynamics and a firing threshold that evolves as an Ornstein-Uhlenbeck process. The formulation of this minimal model is motivated by the experimentally observed widespread variation of neural firing thresholds. We show numerically that the mean first passage time can depend non-monotonically on the noise amplitude. For sufficiently large values of the correlation time of the stochastic threshold the mean first passage time is maximal for non-vanishing noise. We provide an explanation for this effect by analytically transforming the original model into a first passage time problem for Brownian motion. This transformation also allows for a perturbative calculation of the first passage time histograms. In turn this provides quantitative insights into the mechanisms that lead to the non-monotonic behaviour of the mean first passage time. The perturbation expansion is in excellent agreement with direct numerical simulations. The approach developed here can be applied to any deterministic subthreshold dynamics and any Gauss-Markov processes for the firing threshold. This opens up the possibility to incorporate biophysically detailed components into the subthreshold dynamics, rendering our approach a powerful framework that sits between traditional integrate-and-fire models and complex mechanistic descriptions of neural dynamics. American Physical Society 2015-05-07 Article PeerReviewed Braun, Wilhelm, Matthews, Paul C. and Thul, Ruediger (2015) First passage times in integrate-and-fire neurons with stochastic thresholds. Physical Review E, 91 . 052701/1-052701/7. ISSN 1539-3755 Neurons Neural stochasticity http://dx.doi.org/10.1103/PhysRevE.91.052701 doi:10.1103/PhysRevE.91.052701 doi:10.1103/PhysRevE.91.052701 |
| spellingShingle | Neurons Neural stochasticity Braun, Wilhelm Matthews, Paul C. Thul, Ruediger First passage times in integrate-and-fire neurons with stochastic thresholds |
| title | First passage times in integrate-and-fire neurons with stochastic thresholds |
| title_full | First passage times in integrate-and-fire neurons with stochastic thresholds |
| title_fullStr | First passage times in integrate-and-fire neurons with stochastic thresholds |
| title_full_unstemmed | First passage times in integrate-and-fire neurons with stochastic thresholds |
| title_short | First passage times in integrate-and-fire neurons with stochastic thresholds |
| title_sort | first passage times in integrate-and-fire neurons with stochastic thresholds |
| topic | Neurons Neural stochasticity |
| url | https://eprints.nottingham.ac.uk/28677/ https://eprints.nottingham.ac.uk/28677/ https://eprints.nottingham.ac.uk/28677/ |