The impact of cafeteria feeding during lactation in the rat on novel object discrimination in the offspring
There is increasing evidence that hyperenergetic diets impact on memory in rodents. However, it is largely unknown how diets, such as a cafeteria diet (CD), that mimic a Western diet act on learning and memory, in particular when fed during early stages of development. Here, we fed lactating dams a...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Published: |
Cambridge University Press
2014
|
| Online Access: | https://eprints.nottingham.ac.uk/28477/ |
| _version_ | 1848793581508100096 |
|---|---|
| author | Wright, Thomas King, Madeleine Davey, William Langley-Evans, Simon C. Voigt, Jörg-Peter |
| author_facet | Wright, Thomas King, Madeleine Davey, William Langley-Evans, Simon C. Voigt, Jörg-Peter |
| author_sort | Wright, Thomas |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | There is increasing evidence that hyperenergetic diets impact on memory in rodents. However, it is largely unknown how diets, such as a cafeteria diet (CD), that mimic a Western diet act on learning and memory, in particular when fed during early stages of development. Here, we fed lactating dams a cafeteria diet and exposed both male and female offspring to a novel object discrimination (NOD) task, a two-trial test of recognition memory in which rats exposed to two identical objects during a training/familiarisation trial can discriminate a novel from a familiar object during the subsequent choice trial. The choice trial was performed following inter-trial interval (ITI) delays of up to 4 h. Maternal diet did not impact on exploration of the objects by either sex during the familiarisation trial. Control males discriminated the novel from the familiar object indicating intact memory with an ITI of 1h, but not 2 or 4h. CD delayed this natural forgetting in male rats such that discrimination was also evident after a 2h ITI. In contrast, control females exhibited discrimination following both 1 and 2h ITIs, but CD impaired performance. In summary, the present study shows that maternal exposure to CD programmes NOD in the adult. In better performing females dietary programming interferes with NOD whereas NOD was improved in males after lactational CD feeding. |
| first_indexed | 2025-11-14T19:02:34Z |
| format | Article |
| id | nottingham-28477 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:02:34Z |
| publishDate | 2014 |
| publisher | Cambridge University Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-284772020-05-04T20:18:11Z https://eprints.nottingham.ac.uk/28477/ The impact of cafeteria feeding during lactation in the rat on novel object discrimination in the offspring Wright, Thomas King, Madeleine Davey, William Langley-Evans, Simon C. Voigt, Jörg-Peter There is increasing evidence that hyperenergetic diets impact on memory in rodents. However, it is largely unknown how diets, such as a cafeteria diet (CD), that mimic a Western diet act on learning and memory, in particular when fed during early stages of development. Here, we fed lactating dams a cafeteria diet and exposed both male and female offspring to a novel object discrimination (NOD) task, a two-trial test of recognition memory in which rats exposed to two identical objects during a training/familiarisation trial can discriminate a novel from a familiar object during the subsequent choice trial. The choice trial was performed following inter-trial interval (ITI) delays of up to 4 h. Maternal diet did not impact on exploration of the objects by either sex during the familiarisation trial. Control males discriminated the novel from the familiar object indicating intact memory with an ITI of 1h, but not 2 or 4h. CD delayed this natural forgetting in male rats such that discrimination was also evident after a 2h ITI. In contrast, control females exhibited discrimination following both 1 and 2h ITIs, but CD impaired performance. In summary, the present study shows that maternal exposure to CD programmes NOD in the adult. In better performing females dietary programming interferes with NOD whereas NOD was improved in males after lactational CD feeding. Cambridge University Press 2014 Article PeerReviewed Wright, Thomas, King, Madeleine, Davey, William, Langley-Evans, Simon C. and Voigt, Jörg-Peter (2014) The impact of cafeteria feeding during lactation in the rat on novel object discrimination in the offspring. British Journal of Nutrition, 112 . pp. 1933-1937. ISSN 0007-1145 http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=9446882&fileId=S0007114514003134 doi:10.1017/S0007114514003134 doi:10.1017/S0007114514003134 |
| spellingShingle | Wright, Thomas King, Madeleine Davey, William Langley-Evans, Simon C. Voigt, Jörg-Peter The impact of cafeteria feeding during lactation in the rat on novel object discrimination in the offspring |
| title | The impact of cafeteria feeding during lactation in the rat on novel object discrimination in the offspring |
| title_full | The impact of cafeteria feeding during lactation in the rat on novel object discrimination in the offspring |
| title_fullStr | The impact of cafeteria feeding during lactation in the rat on novel object discrimination in the offspring |
| title_full_unstemmed | The impact of cafeteria feeding during lactation in the rat on novel object discrimination in the offspring |
| title_short | The impact of cafeteria feeding during lactation in the rat on novel object discrimination in the offspring |
| title_sort | impact of cafeteria feeding during lactation in the rat on novel object discrimination in the offspring |
| url | https://eprints.nottingham.ac.uk/28477/ https://eprints.nottingham.ac.uk/28477/ https://eprints.nottingham.ac.uk/28477/ |