A glycopeptide dendrimer inhibitor of the galactose specific lectin LecA & of Pseudomonas aeruginosa biofilms

A glycopeptide dendrimer inhibitor of the galactose specific lectin LecA & of Pseudomonas aeruginosa biofilms

Biofilm inhibition is achieved with a phenylgalactosyl peptide dendrimer (see picture) that binds to the galactose-specific lectin LecA of P. aeruginosa. The multivalency of the ligands is critical for biofilm inhibition, although the nature of the linker between the peptide dendrimer and the galact...

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Main Authors: Kadam, Rameshwar U., Bergmann, Myriam, Hurley, Matthew, Garg, Divita, Cacciarini, Martina, Swiderska, Magdalena A., Nativi, Cristina, Sattler, Michael, Smyth, Alan R., Williams, Paul, Cámara, Miguel, Stocker, Achim, Darbre, Tamis, Reymond, Jean-Louis
Format: Article
Published: Wiley-VCH Verlag 2011
Online Access:https://eprints.nottingham.ac.uk/2843/

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