A glycopeptide dendrimer inhibitor of the galactose specific lectin LecA & of Pseudomonas aeruginosa biofilms
Biofilm inhibition is achieved with a phenylgalactosyl peptide dendrimer (see picture) that binds to the galactose-specific lectin LecA of P. aeruginosa. The multivalency of the ligands is critical for biofilm inhibition, although the nature of the linker between the peptide dendrimer and the galact...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
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Wiley-VCH Verlag
2011
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| Online Access: | https://eprints.nottingham.ac.uk/2843/ |
| _version_ | 1848790890144858112 |
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| author | Kadam, Rameshwar U. Bergmann, Myriam Hurley, Matthew Garg, Divita Cacciarini, Martina Swiderska, Magdalena A. Nativi, Cristina Sattler, Michael Smyth, Alan R. Williams, Paul Cámara, Miguel Stocker, Achim Darbre, Tamis Reymond, Jean-Louis |
| author_facet | Kadam, Rameshwar U. Bergmann, Myriam Hurley, Matthew Garg, Divita Cacciarini, Martina Swiderska, Magdalena A. Nativi, Cristina Sattler, Michael Smyth, Alan R. Williams, Paul Cámara, Miguel Stocker, Achim Darbre, Tamis Reymond, Jean-Louis |
| author_sort | Kadam, Rameshwar U. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Biofilm inhibition is achieved with a phenylgalactosyl peptide dendrimer (see picture) that binds to the galactose-specific lectin LecA of P. aeruginosa. The multivalency of the ligands is critical for biofilm inhibition, although the nature of the linker between the peptide dendrimer and the galactose can provide additional contacts to the lectin and also has an effect on the interaction. |
| first_indexed | 2025-11-14T18:19:48Z |
| format | Article |
| id | nottingham-2843 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:19:48Z |
| publishDate | 2011 |
| publisher | Wiley-VCH Verlag |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-28432020-05-04T16:31:42Z https://eprints.nottingham.ac.uk/2843/ A glycopeptide dendrimer inhibitor of the galactose specific lectin LecA & of Pseudomonas aeruginosa biofilms Kadam, Rameshwar U. Bergmann, Myriam Hurley, Matthew Garg, Divita Cacciarini, Martina Swiderska, Magdalena A. Nativi, Cristina Sattler, Michael Smyth, Alan R. Williams, Paul Cámara, Miguel Stocker, Achim Darbre, Tamis Reymond, Jean-Louis Biofilm inhibition is achieved with a phenylgalactosyl peptide dendrimer (see picture) that binds to the galactose-specific lectin LecA of P. aeruginosa. The multivalency of the ligands is critical for biofilm inhibition, although the nature of the linker between the peptide dendrimer and the galactose can provide additional contacts to the lectin and also has an effect on the interaction. Wiley-VCH Verlag 2011-11-04 Article PeerReviewed Kadam, Rameshwar U., Bergmann, Myriam, Hurley, Matthew, Garg, Divita, Cacciarini, Martina, Swiderska, Magdalena A., Nativi, Cristina, Sattler, Michael, Smyth, Alan R., Williams, Paul, Cámara, Miguel, Stocker, Achim, Darbre, Tamis and Reymond, Jean-Louis (2011) A glycopeptide dendrimer inhibitor of the galactose specific lectin LecA & of Pseudomonas aeruginosa biofilms. Angewandte Chemie International Edition, 50 (45). pp. 10631-10635. ISSN 1433-7851 http://onlinelibrary.wiley.com/doi/10.1002/anie.201104342/abstract doi:10.1002/anie.201104342 doi:10.1002/anie.201104342 |
| spellingShingle | Kadam, Rameshwar U. Bergmann, Myriam Hurley, Matthew Garg, Divita Cacciarini, Martina Swiderska, Magdalena A. Nativi, Cristina Sattler, Michael Smyth, Alan R. Williams, Paul Cámara, Miguel Stocker, Achim Darbre, Tamis Reymond, Jean-Louis A glycopeptide dendrimer inhibitor of the galactose specific lectin LecA & of Pseudomonas aeruginosa biofilms |
| title | A glycopeptide dendrimer inhibitor of the galactose specific lectin LecA & of Pseudomonas aeruginosa biofilms |
| title_full | A glycopeptide dendrimer inhibitor of the galactose specific lectin LecA & of Pseudomonas aeruginosa biofilms |
| title_fullStr | A glycopeptide dendrimer inhibitor of the galactose specific lectin LecA & of Pseudomonas aeruginosa biofilms |
| title_full_unstemmed | A glycopeptide dendrimer inhibitor of the galactose specific lectin LecA & of Pseudomonas aeruginosa biofilms |
| title_short | A glycopeptide dendrimer inhibitor of the galactose specific lectin LecA & of Pseudomonas aeruginosa biofilms |
| title_sort | glycopeptide dendrimer inhibitor of the galactose specific lectin leca & of pseudomonas aeruginosa biofilms |
| url | https://eprints.nottingham.ac.uk/2843/ https://eprints.nottingham.ac.uk/2843/ https://eprints.nottingham.ac.uk/2843/ |