Delayed publications of clinical trials in cystic fibrosis
Background: When the publication of important trial data is delayed, or data are never published, this will prevent the proper practice of evidence based medicine through robust systematic reviews. Clinical trial registries allow researchers to interrogate the trial protocol and afford the opp...
| Main Authors: | , , |
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| Format: | Article |
| Published: |
Elsevier
2011
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| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/2842/ |
| _version_ | 1848790889785196544 |
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| author | Hurley, M.N. Prayle, A.P. Smyth, Alan R. |
| author_facet | Hurley, M.N. Prayle, A.P. Smyth, Alan R. |
| author_sort | Hurley, M.N. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background:
When the publication of important trial data is delayed, or data are never published, this will prevent the proper practice of evidence based medicine through robust systematic reviews. Clinical trial registries allow researchers to interrogate the trial protocol and afford the opportunity to identify studies that have been completed and so determine the time lag between completion and publication.
Methods:
We searched ClinicalTrials.gov with the keywords ‘cystic fibrosis’. Intervention trials which had completed 1st Jan 1998–31st Dec 2010 were selected. Time to publication in a peer-reviewed journal was calculated. Survival analyses using the log rank test were undertaken.
Results:
We identified 142 records. Of these, 62 had full paper publications. The median time to publication was 3.25 years. Phase of study (phase one studies more delayed, p = 0.024) but not source of funding (p = 0.34) was associated with time to publication.
Conclusions:
Clinical trials in cystic fibrosis take a considerable amount of time to report their findings. More importantly, a large number of trials fail to report at all. |
| first_indexed | 2025-11-14T18:19:47Z |
| format | Article |
| id | nottingham-2842 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:19:47Z |
| publishDate | 2011 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-28422020-05-04T16:30:56Z https://eprints.nottingham.ac.uk/2842/ Delayed publications of clinical trials in cystic fibrosis Hurley, M.N. Prayle, A.P. Smyth, Alan R. Background: When the publication of important trial data is delayed, or data are never published, this will prevent the proper practice of evidence based medicine through robust systematic reviews. Clinical trial registries allow researchers to interrogate the trial protocol and afford the opportunity to identify studies that have been completed and so determine the time lag between completion and publication. Methods: We searched ClinicalTrials.gov with the keywords ‘cystic fibrosis’. Intervention trials which had completed 1st Jan 1998–31st Dec 2010 were selected. Time to publication in a peer-reviewed journal was calculated. Survival analyses using the log rank test were undertaken. Results: We identified 142 records. Of these, 62 had full paper publications. The median time to publication was 3.25 years. Phase of study (phase one studies more delayed, p = 0.024) but not source of funding (p = 0.34) was associated with time to publication. Conclusions: Clinical trials in cystic fibrosis take a considerable amount of time to report their findings. More importantly, a large number of trials fail to report at all. Elsevier 2011-09-01 Article PeerReviewed Hurley, M.N., Prayle, A.P. and Smyth, Alan R. (2011) Delayed publications of clinical trials in cystic fibrosis. Journal of Cystic Fibrosis, 11 (1). pp. 14-17. ISSN 1873-5010 Cystic fibrosis Publication bias Clinical trials http://www.sciencedirect.com/science/article/pii/S1569199311001378# doi:10.1016/j.jcf.2011.08.004 doi:10.1016/j.jcf.2011.08.004 |
| spellingShingle | Cystic fibrosis Publication bias Clinical trials Hurley, M.N. Prayle, A.P. Smyth, Alan R. Delayed publications of clinical trials in cystic fibrosis |
| title | Delayed publications of clinical trials in cystic fibrosis |
| title_full | Delayed publications of clinical trials in cystic fibrosis |
| title_fullStr | Delayed publications of clinical trials in cystic fibrosis |
| title_full_unstemmed | Delayed publications of clinical trials in cystic fibrosis |
| title_short | Delayed publications of clinical trials in cystic fibrosis |
| title_sort | delayed publications of clinical trials in cystic fibrosis |
| topic | Cystic fibrosis Publication bias Clinical trials |
| url | https://eprints.nottingham.ac.uk/2842/ https://eprints.nottingham.ac.uk/2842/ https://eprints.nottingham.ac.uk/2842/ |