Neural primacy of the salience processing system in schizophrenia
For effective information processing, two large-scale distributed neural networks appear to be critical: a multimodal executive system anchored on the dorsolateral prefrontal cortex (DLPFC) and a salience system anchored on the anterior insula. Aberrant interaction among distributed networks is a fe...
| Main Authors: | , , , , |
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| Format: | Article |
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Elsevier
2013
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| Online Access: | https://eprints.nottingham.ac.uk/2826/ |
| _version_ | 1848790885894979584 |
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| author | Palaniyappan, Lena Simmonite, M. White, T.P. Liddle, E.B. Liddle, P.F. |
| author_facet | Palaniyappan, Lena Simmonite, M. White, T.P. Liddle, E.B. Liddle, P.F. |
| author_sort | Palaniyappan, Lena |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | For effective information processing, two large-scale distributed neural networks appear to be critical: a multimodal executive system anchored on the dorsolateral prefrontal cortex (DLPFC) and a salience system anchored on the anterior insula. Aberrant interaction among distributed networks is a feature of psychiatric disorders such as schizophrenia. We used whole-brain Granger causal modeling using resting fMRI and observed a significant failure of both the feedforward and reciprocal influence between the insula and the DLPFC in schizophrenia. Further, a significant failure of directed influence from bilateral visual cortices to the insula was also seen in patients. These findings provide compelling evidence for a breakdown of the salience-execution loop in the clinical expression of psychosis. In addition, this offers a parsimonious explanation for the often-observed “frontal inefficiency,” the failure to recruit prefrontal system when salient or novel information becomes available in patients with schizophrenia. |
| first_indexed | 2025-11-14T18:19:44Z |
| format | Article |
| id | nottingham-2826 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:19:44Z |
| publishDate | 2013 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-28262020-05-04T16:38:23Z https://eprints.nottingham.ac.uk/2826/ Neural primacy of the salience processing system in schizophrenia Palaniyappan, Lena Simmonite, M. White, T.P. Liddle, E.B. Liddle, P.F. For effective information processing, two large-scale distributed neural networks appear to be critical: a multimodal executive system anchored on the dorsolateral prefrontal cortex (DLPFC) and a salience system anchored on the anterior insula. Aberrant interaction among distributed networks is a feature of psychiatric disorders such as schizophrenia. We used whole-brain Granger causal modeling using resting fMRI and observed a significant failure of both the feedforward and reciprocal influence between the insula and the DLPFC in schizophrenia. Further, a significant failure of directed influence from bilateral visual cortices to the insula was also seen in patients. These findings provide compelling evidence for a breakdown of the salience-execution loop in the clinical expression of psychosis. In addition, this offers a parsimonious explanation for the often-observed “frontal inefficiency,” the failure to recruit prefrontal system when salient or novel information becomes available in patients with schizophrenia. Elsevier 2013-08-21 Article PeerReviewed Palaniyappan, Lena, Simmonite, M., White, T.P., Liddle, E.B. and Liddle, P.F. (2013) Neural primacy of the salience processing system in schizophrenia. Neuron, 79 (4). pp. 814-828. ISSN 0896-6273 http://www.sciencedirect.com/science/article/pii/S0896627313005436# doi:10.1016/j.neuron.2013.06.027 doi:10.1016/j.neuron.2013.06.027 |
| spellingShingle | Palaniyappan, Lena Simmonite, M. White, T.P. Liddle, E.B. Liddle, P.F. Neural primacy of the salience processing system in schizophrenia |
| title | Neural primacy of the salience processing system in schizophrenia |
| title_full | Neural primacy of the salience processing system in schizophrenia |
| title_fullStr | Neural primacy of the salience processing system in schizophrenia |
| title_full_unstemmed | Neural primacy of the salience processing system in schizophrenia |
| title_short | Neural primacy of the salience processing system in schizophrenia |
| title_sort | neural primacy of the salience processing system in schizophrenia |
| url | https://eprints.nottingham.ac.uk/2826/ https://eprints.nottingham.ac.uk/2826/ https://eprints.nottingham.ac.uk/2826/ |