Investigating the micro-rheology of the vitreous humor using an optically trapped local probe
We demonstrate that an optically trapped silica bead can be used as a local probe to measure the micro-rheology of the vitreous humor. The Brownian motion of the bead was observed using a fast camera and the micro-rheology determined by analysis of the time-dependent mean-square displacement of the...
| Main Authors: | , , , , , |
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| Format: | Article |
| Published: |
IOP Publishing
2014
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| Online Access: | https://eprints.nottingham.ac.uk/2819/ |
| _version_ | 1848790883637395456 |
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| author | Watts, Fiona Tan, Lay Ean Wilson, Clive G. Girkin, John M. Tassieri, Manlio Wright, Amanda J. |
| author_facet | Watts, Fiona Tan, Lay Ean Wilson, Clive G. Girkin, John M. Tassieri, Manlio Wright, Amanda J. |
| author_sort | Watts, Fiona |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | We demonstrate that an optically trapped silica bead can be used as a local probe to measure the micro-rheology of the vitreous humor. The Brownian motion of the bead was observed using a fast camera and the micro-rheology determined by analysis of the time-dependent mean-square displacement of the bead. We observed regions of the vitreous that showed different degrees of viscoelasticity, along with the homogeneous and inhomogeneous nature of different regions. The motivation behind this study is to understand the vitreous structure, in particular changes due to aging, allowing more confident prediction of pharmaceutical drug behavior and delivery within the vitreous humor. |
| first_indexed | 2025-11-14T18:19:42Z |
| format | Article |
| id | nottingham-2819 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:19:42Z |
| publishDate | 2014 |
| publisher | IOP Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-28192020-05-04T16:40:24Z https://eprints.nottingham.ac.uk/2819/ Investigating the micro-rheology of the vitreous humor using an optically trapped local probe Watts, Fiona Tan, Lay Ean Wilson, Clive G. Girkin, John M. Tassieri, Manlio Wright, Amanda J. We demonstrate that an optically trapped silica bead can be used as a local probe to measure the micro-rheology of the vitreous humor. The Brownian motion of the bead was observed using a fast camera and the micro-rheology determined by analysis of the time-dependent mean-square displacement of the bead. We observed regions of the vitreous that showed different degrees of viscoelasticity, along with the homogeneous and inhomogeneous nature of different regions. The motivation behind this study is to understand the vitreous structure, in particular changes due to aging, allowing more confident prediction of pharmaceutical drug behavior and delivery within the vitreous humor. IOP Publishing 2014-01-01 Article PeerReviewed Watts, Fiona, Tan, Lay Ean, Wilson, Clive G., Girkin, John M., Tassieri, Manlio and Wright, Amanda J. (2014) Investigating the micro-rheology of the vitreous humor using an optically trapped local probe. Journal of Optics, 16 (1). 015301. ISSN 2040-8986 http://iopscience.iop.org/2040-8986/16/1/015301/ doi:10.1088/2040-8978/16/1/015301 doi:10.1088/2040-8978/16/1/015301 |
| spellingShingle | Watts, Fiona Tan, Lay Ean Wilson, Clive G. Girkin, John M. Tassieri, Manlio Wright, Amanda J. Investigating the micro-rheology of the vitreous humor using an optically trapped local probe |
| title | Investigating the micro-rheology of the vitreous humor using an optically trapped local probe |
| title_full | Investigating the micro-rheology of the vitreous humor using an optically trapped local probe |
| title_fullStr | Investigating the micro-rheology of the vitreous humor using an optically trapped local probe |
| title_full_unstemmed | Investigating the micro-rheology of the vitreous humor using an optically trapped local probe |
| title_short | Investigating the micro-rheology of the vitreous humor using an optically trapped local probe |
| title_sort | investigating the micro-rheology of the vitreous humor using an optically trapped local probe |
| url | https://eprints.nottingham.ac.uk/2819/ https://eprints.nottingham.ac.uk/2819/ https://eprints.nottingham.ac.uk/2819/ |