A methodology for automatic classification of breast cancer immunohistochemical data using semi-supervised fuzzy c-means
Previously, a semi-manual method was used to identify six novel and clinically useful classes in the Nottingham Tenovus Breast Cancer dataset. 663 out of 1,076 patients were classified. The objectives of our work is three folds. Firstly, our primary objective is to use one single automatic method (p...
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| Format: | Article |
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Springer Verlag
2014
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| Online Access: | https://eprints.nottingham.ac.uk/28154/ |
| _version_ | 1848793517686521856 |
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| author | Lai, Daphne Teck Ching Garibaldi, Jonathan M. Soria, Daniele Roadknight, Christopher M. |
| author_facet | Lai, Daphne Teck Ching Garibaldi, Jonathan M. Soria, Daniele Roadknight, Christopher M. |
| author_sort | Lai, Daphne Teck Ching |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Previously, a semi-manual method was used to identify six novel and clinically useful classes in the Nottingham Tenovus Breast Cancer dataset. 663 out of 1,076 patients were classified. The objectives of our work is three folds. Firstly, our primary objective is to use one single automatic method (post-initialisation) to reproduce the six classes for the 663 patients and to classify the remaining 413 patients. Secondly, we explore using semi-supervised fuzzy c-means with various distance metrics and initialisation techniques to achieve this. Thirdly, the clinical characteristics of the 413 patients are examined by comparing with the 663 patients. Our experiments use various amount of labelled data and 10-fold cross validation to reproduce and evaluate the classification. ssFCM with Euclidean distance and initialisation technique by Katsavounidis et al. produced the best results. It is then used to classify the 413 patients. Visual evaluation of the 413 patients’ classifications revealed common characteristics as those previously reported. Examination of clinical characteristics indicates significant associations between classification and clinical parameters. More importantly, association between classification and survival based on the survival curves is shown. |
| first_indexed | 2025-11-14T19:01:34Z |
| format | Article |
| id | nottingham-28154 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:01:34Z |
| publishDate | 2014 |
| publisher | Springer Verlag |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-281542020-05-04T20:13:28Z https://eprints.nottingham.ac.uk/28154/ A methodology for automatic classification of breast cancer immunohistochemical data using semi-supervised fuzzy c-means Lai, Daphne Teck Ching Garibaldi, Jonathan M. Soria, Daniele Roadknight, Christopher M. Previously, a semi-manual method was used to identify six novel and clinically useful classes in the Nottingham Tenovus Breast Cancer dataset. 663 out of 1,076 patients were classified. The objectives of our work is three folds. Firstly, our primary objective is to use one single automatic method (post-initialisation) to reproduce the six classes for the 663 patients and to classify the remaining 413 patients. Secondly, we explore using semi-supervised fuzzy c-means with various distance metrics and initialisation techniques to achieve this. Thirdly, the clinical characteristics of the 413 patients are examined by comparing with the 663 patients. Our experiments use various amount of labelled data and 10-fold cross validation to reproduce and evaluate the classification. ssFCM with Euclidean distance and initialisation technique by Katsavounidis et al. produced the best results. It is then used to classify the 413 patients. Visual evaluation of the 413 patients’ classifications revealed common characteristics as those previously reported. Examination of clinical characteristics indicates significant associations between classification and clinical parameters. More importantly, association between classification and survival based on the survival curves is shown. Springer Verlag 2014-09 Article PeerReviewed Lai, Daphne Teck Ching, Garibaldi, Jonathan M., Soria, Daniele and Roadknight, Christopher M. (2014) A methodology for automatic classification of breast cancer immunohistochemical data using semi-supervised fuzzy c-means. Central European Journal of Operations Research, 22 (3). pp. 475-499. ISSN 1435-246X Breast cancer Fuzzy clustering Molecular classification http://link.springer.com/article/10.1007/s10100-013-0318-3 doi:10.1007/s10100-013-0318-3 doi:10.1007/s10100-013-0318-3 |
| spellingShingle | Breast cancer Fuzzy clustering Molecular classification Lai, Daphne Teck Ching Garibaldi, Jonathan M. Soria, Daniele Roadknight, Christopher M. A methodology for automatic classification of breast cancer immunohistochemical data using semi-supervised fuzzy c-means |
| title | A methodology for automatic classification of breast cancer immunohistochemical data using semi-supervised fuzzy c-means |
| title_full | A methodology for automatic classification of breast cancer immunohistochemical data using semi-supervised fuzzy c-means |
| title_fullStr | A methodology for automatic classification of breast cancer immunohistochemical data using semi-supervised fuzzy c-means |
| title_full_unstemmed | A methodology for automatic classification of breast cancer immunohistochemical data using semi-supervised fuzzy c-means |
| title_short | A methodology for automatic classification of breast cancer immunohistochemical data using semi-supervised fuzzy c-means |
| title_sort | methodology for automatic classification of breast cancer immunohistochemical data using semi-supervised fuzzy c-means |
| topic | Breast cancer Fuzzy clustering Molecular classification |
| url | https://eprints.nottingham.ac.uk/28154/ https://eprints.nottingham.ac.uk/28154/ https://eprints.nottingham.ac.uk/28154/ |