Molecular modelling of the cannabinoid receptors: structure-based design, synthesis and pharmacological evaluation of novel ligands based on the fenofibrate scaffold

QR Code

Molecular modelling of the cannabinoid receptors: structure-based design, synthesis and pharmacological evaluation of novel ligands based on the fenofibrate scaffold

The cannabinoid receptors CB1 and CB2, which belong to the rhodopsin family of GPCRs, are implicated in the pathology of various disease states. As drugs targeting these receptors remain limited, novel cannabinoid receptor ligands represent an unmet need with substantial therapeutic potential. We pr...

Full description

Bibliographic Details
Main Author:	Loo, Jason S. E.
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2015
Online Access:	https://eprints.nottingham.ac.uk/28019/

Similar Items

Novel fenofibrate derivatives as cannabinoid receptor ligands
by: Spencer, Sarah Jane
Published: (2011)

Design, synthesis and evaluation of fluorescent CB2 cannabinoid receptor ligands
by: Holt, Christopher James
Published: (2009)

Design, synthesis and pharmacological evaluation of novel fluorescent ligands for the mu-opioid receptor
by: Marshall, William
Published: (2021)

Effect of cannabinoid receptor ligands on microglial cell functions
by: Hassan, Samia
Published: (2013)

Investigating ligand-directed signalling at the cannabinoid receptor 2
by: Hourani, Wafa
Published: (2019)

Fluorescent cannabinoids: Stratagies towards the synthesis of fluorescently labelled CB2 receptor ligands
by: Yates, Andrew Stephen
Published: (2005)

Investigating the molecular basis of biased signalling at cannabinoid receptors
by: Dennis, Morgan Jane
Published: (2023)

Structural exploration of cannabinoid receptors using computational methods
by: Murali, Lahari
Published: (2020)

Similarity- and substructure-based development of β2-adrenergic receptor ligands based on unusual scaffolds
by: Schmidt, Denis, et al.
Published: (2017)

Synthesis and pharmacology of new psychoactive substance 5F-CUMYL-P7AICA, a scaffold- hopping analog of synthetic cannabinoid receptor agonists 5F-CUMYL-PICA and 5F-CUMYL-PINACA
by: Banister, S., et al.
Published: (2018)

Assessment of GPR18 pairing with putative cannabinoid ligands
by: Abdulrazzaq, Ghayth
Published: (2018)

Molecular characterization of cannabinoids and free fatty acid receptors in human and rat skeletal muscle
by: Shermado, Fairouz M.
Published: (2014)

Design and synthesis of novel P2Y2 receptor ligands
by: Conroy, S.
Published: (2018)

Discovering the molecular basis for ligand pharmacological activity on β-adrenoceptors
by: Bunsuz, Asuman
Published: (2023)

Synthesis and biological evaluation of novel compounds as potential modulators of cannabinoid signalling pathways
by: De Bank, Paul A.
Published: (2001)

Molecular modeling of muscarinic acetylcholine receptors: Structural basis of ligand-receptor interactions / Chin Sek Peng
by: Chin, Sek Peng
Published: (2015)

Kinetic studies of dopamine D2 receptor molecular pharmacology
by: Keen, Alastair C.
Published: (2021)

A study of functional selectivity at the cannabinoid type 1 receptor
by: Priestley, Richard
Published: (2015)

The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation
by: Pieiro, R., et al.
Published: (2011)

Preparation And Evaluation Of Fenofibrate-Gelucire 44/14 Solid Dispersions
by: Al-Dhalli, Samer
Published: (2007)

Imaging Cannabinoid Receptors: A Brief Collection of Covalent and Fluorescent Probes for CB1 and CB2 Receptors
by: Hamilton, A.J., et al.
Published: (2021)

Synthesis, biological evaluation, and utility of fluorescent ligands targeting the μ-opioid receptor
by: Schembri, Luke S., et al.
Published: (2015)

Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold
by: Schwehm, Carolin, et al.
Published: (2015)

Structure-based and ligand-based virtual screening of novel methyltransferase inhibitors of the dengue virus.
by: See, Ven Lim, et al.
Published: (2011)

Cannabinoid CB1 receptor binding and acetylcholinesterase inhibitory activity of Sceletium tortuosum L.
by: Lubbe, A., et al.
Published: (2010)

Cannabinoid CB1 receptor binding and acetylcholinesterase inhibitory activity of Sceletium tortuosum L.
by: Lubbe, Andrea, et al.
Published: (2010)

An evaluation of DREADD receptor pharmacology in recombinant cells and astrocytes
by: Carpenter, Jessica
Published: (2020)

The endocannabinoid, anandamide, induces cannabinoid receptor-independent cell death in renal proximal tubule cells
by: Schlosser, Monika, et al.
Published: (2017)

NanoBRET to probe ligand-receptor and receptor-receptor interactions in living cells
by: Carvalheira Alcobia, Diana
Published: (2019)

Investigating the pharmacology of ladybird alkaloids on ligand-gated ion channels
by: Patel, Rohit
Published: (2018)

Optimisation of Peptide Linker-based Fluorescent Ligands for the Histamine H1 Receptor
by: Kok, Zhi Yuan
Published: (2020)

Design, Synthesis, and Evaluation of New P2Y2 Receptor Antagonists and Fluorescent Ligands
by: Knight, Rebecca
Published: (2025)

Potential novel inhibitors of trypanosomatid phosphoglycerate mutases through ligand-based and structure-based in silico approaches
by: Ahmad Fuad, Fazia Adyani, et al.
Published: (2015)

Pharmacological analysis and structure determination of 7-methylcyanopindolol–bound b1-adrenergic receptor
by: Sato, Tomomi, et al.
Published: (2015)

Zerumbone ameliorates neuropathic pain symptoms via cannabinoid and ppar receptors using in vivo and in silico models
by: Chia, Jasmine Siew Min, et al.
Published: (2021)

Encapsulation of fenofibrate in solid lipid microparticles by central composite face-centred guided by electrospray
by: Azhar, Muhammad Fitri, et al.
Published: (2020)

Fragment-based discovery of subtype-selective adenosine receptor ligands from homology models
by: Ranganathan, Anirudh, et al.
Published: (2015)

CB1 cannabinoid receptor in brain mesolimbic system of mitragynine-sensitised albina wastar rats as a candidate molecular terget in mitragyna speciosa (KETUM) addiction
by: Mustapha, Muzaimi
Published: (2015)

The effects of cannabinoids on insulin secretion
by: Anderson, Richard L.
Published: (2011)

Novel concepts in HDL pharmacology
by: Remaley, A., et al.
Published: (2014)