Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling
Sir James Black developed β-blockers, one of the most useful groups of drugs in use today. Not only are they being used for their original purpose to treat angina and cardiac arrhythmias, but they are also effective therapeutics for hypertension, cardiac failure, glaucoma, migraine and anxiety. Rece...
| Main Authors: | , , |
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| Format: | Article |
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Elsevier
2011
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| Online Access: | https://eprints.nottingham.ac.uk/2796/ |
| _version_ | 1848790877840867328 |
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| author | Baker, Jillian G. Hill, Stephen J. Summers, Roger J. |
| author_facet | Baker, Jillian G. Hill, Stephen J. Summers, Roger J. |
| author_sort | Baker, Jillian G. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Sir James Black developed β-blockers, one of the most useful groups of drugs in use today. Not only are they being used for their original purpose to treat angina and cardiac arrhythmias, but they are also effective therapeutics for hypertension, cardiac failure, glaucoma, migraine and anxiety. Recent studies suggest that they might also prove useful in diseases as diverse as osteoporosis, cancer and malaria. They have also provided some of the most useful tools for pharmacological research that have underpinned the development of concepts such as receptor subtype selectivity, agonism and inverse agonism, and ligand-directed signalling bias. This article examines how β-blockers have evolved and indicates how they might be used in the future. |
| first_indexed | 2025-11-14T18:19:36Z |
| format | Article |
| id | nottingham-2796 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:19:36Z |
| publishDate | 2011 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-27962020-05-04T20:23:22Z https://eprints.nottingham.ac.uk/2796/ Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling Baker, Jillian G. Hill, Stephen J. Summers, Roger J. Sir James Black developed β-blockers, one of the most useful groups of drugs in use today. Not only are they being used for their original purpose to treat angina and cardiac arrhythmias, but they are also effective therapeutics for hypertension, cardiac failure, glaucoma, migraine and anxiety. Recent studies suggest that they might also prove useful in diseases as diverse as osteoporosis, cancer and malaria. They have also provided some of the most useful tools for pharmacological research that have underpinned the development of concepts such as receptor subtype selectivity, agonism and inverse agonism, and ligand-directed signalling bias. This article examines how β-blockers have evolved and indicates how they might be used in the future. Elsevier 2011-04 Article PeerReviewed Baker, Jillian G., Hill, Stephen J. and Summers, Roger J. (2011) Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling. Trends in Pharmacological Sciences, 32 (4). pp. 227-234. ISSN 0165-6147 http://www.sciencedirect.com/science/article/pii/S0165614711000320 doi:10.1016/j.tips.2011.02.010 doi:10.1016/j.tips.2011.02.010 |
| spellingShingle | Baker, Jillian G. Hill, Stephen J. Summers, Roger J. Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling |
| title | Evolution of β-blockers: from anti-anginal drugs to
ligand-directed signalling |
| title_full | Evolution of β-blockers: from anti-anginal drugs to
ligand-directed signalling |
| title_fullStr | Evolution of β-blockers: from anti-anginal drugs to
ligand-directed signalling |
| title_full_unstemmed | Evolution of β-blockers: from anti-anginal drugs to
ligand-directed signalling |
| title_short | Evolution of β-blockers: from anti-anginal drugs to
ligand-directed signalling |
| title_sort | evolution of β-blockers: from anti-anginal drugs to
ligand-directed signalling |
| url | https://eprints.nottingham.ac.uk/2796/ https://eprints.nottingham.ac.uk/2796/ https://eprints.nottingham.ac.uk/2796/ |