Inhibition of mammalian nicotinic acetylcholine receptors by philanthotoxin analogues is strongly influenced by subunit composition

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Inhibition of mammalian nicotinic acetylcholine receptors by philanthotoxin analogues is strongly influenced by subunit composition

Philanthotoxin-433 (PhTX-433) is an active component of the Egyptian solitary digger wasp, Philanthus triangulum, venom which non-selectively inhibits several excitatory ion channels. With the aim of improving potency and selectivity, several synthetic analogues were developed based on the single or...

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Bibliographic Details
Main Author:	Kachel, Hamid Saeid
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2015
Subjects:	Nicotinic acetylcholine receptor; philanthotoxin; channel block; voltage clamp; xenopus oocytes.
Online Access:	https://eprints.nottingham.ac.uk/27912/

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