Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer
Ovarian cancer is routinely treated with surgery and platinum-based chemotherapy. Resistance is a major obstacle in the efficacy of this chemotherapy regimen and the ability to identify those patients at risk of developing resistance is of considerable clinical importance. The expression of calpai...
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| Format: | Article |
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Wiley
2012
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| Online Access: | https://eprints.nottingham.ac.uk/2786/ |
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| author | Storr, Sarah J. Safuan, Sabreena Woolston, Caroline M. Abdel-Fatah, Tarek Deen, Suha Chan, Stephen Y. Martin, Stewart G. |
| author_facet | Storr, Sarah J. Safuan, Sabreena Woolston, Caroline M. Abdel-Fatah, Tarek Deen, Suha Chan, Stephen Y. Martin, Stewart G. |
| author_sort | Storr, Sarah J. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Ovarian cancer is routinely treated with surgery and platinum-based chemotherapy. Resistance is a major obstacle in the efficacy of this chemotherapy
regimen and the ability to identify those patients at risk of developing resistance is of considerable clinical importance. The expression of
calpain-1, calpain-2 and calpastatin were determined using standard immunohistochemistry on a tissue microarray of 154 primary ovarian carcinomas
from patients subsequently treated with platinum-based adjuvant chemotherapy. High levels of calpain-2 expression was significantly associated
with platinum resistant tumours (P = 0.031). Furthermore, high expression of calpain-2 was significantly associated with progression-free
(P = 0.049) and overall survival (P = 0.006) in this cohort. The association between calpain-2 expression and overall survival remained significant
in multivariate analysis accounting for tumour grade, stage, optimal debulking and platinum sensitivity (hazard ratio = 2.174; 95% confidence
interval = 1.144–4.130; P = 0.018). The results suggest that determining calpain-2 expression in ovarian carcinomas may allow prognostic stratification
of patients treated with surgery and platinum-based chemotherapy. The findings of this study warrant validation in a larger clinical cohort. |
| first_indexed | 2025-11-14T18:19:33Z |
| format | Article |
| id | nottingham-2786 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:19:33Z |
| publishDate | 2012 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-27862020-05-04T20:21:19Z https://eprints.nottingham.ac.uk/2786/ Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer Storr, Sarah J. Safuan, Sabreena Woolston, Caroline M. Abdel-Fatah, Tarek Deen, Suha Chan, Stephen Y. Martin, Stewart G. Ovarian cancer is routinely treated with surgery and platinum-based chemotherapy. Resistance is a major obstacle in the efficacy of this chemotherapy regimen and the ability to identify those patients at risk of developing resistance is of considerable clinical importance. The expression of calpain-1, calpain-2 and calpastatin were determined using standard immunohistochemistry on a tissue microarray of 154 primary ovarian carcinomas from patients subsequently treated with platinum-based adjuvant chemotherapy. High levels of calpain-2 expression was significantly associated with platinum resistant tumours (P = 0.031). Furthermore, high expression of calpain-2 was significantly associated with progression-free (P = 0.049) and overall survival (P = 0.006) in this cohort. The association between calpain-2 expression and overall survival remained significant in multivariate analysis accounting for tumour grade, stage, optimal debulking and platinum sensitivity (hazard ratio = 2.174; 95% confidence interval = 1.144–4.130; P = 0.018). The results suggest that determining calpain-2 expression in ovarian carcinomas may allow prognostic stratification of patients treated with surgery and platinum-based chemotherapy. The findings of this study warrant validation in a larger clinical cohort. Wiley 2012-10 Article PeerReviewed Storr, Sarah J., Safuan, Sabreena, Woolston, Caroline M., Abdel-Fatah, Tarek, Deen, Suha, Chan, Stephen Y. and Martin, Stewart G. (2012) Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer. Journal of Cellular and Molecular Medicine, 16 (10). pp. 2422-2428. ISSN 1582-1838 http://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2012.01559.x/abstract doi:10.1111/j.1582-4934.2012.01559.x doi:10.1111/j.1582-4934.2012.01559.x |
| spellingShingle | Storr, Sarah J. Safuan, Sabreena Woolston, Caroline M. Abdel-Fatah, Tarek Deen, Suha Chan, Stephen Y. Martin, Stewart G. Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer |
| title | Calpain-2 expression is associated with response to platinum
based chemotherapy, progression-free and overall survival in
ovarian cancer |
| title_full | Calpain-2 expression is associated with response to platinum
based chemotherapy, progression-free and overall survival in
ovarian cancer |
| title_fullStr | Calpain-2 expression is associated with response to platinum
based chemotherapy, progression-free and overall survival in
ovarian cancer |
| title_full_unstemmed | Calpain-2 expression is associated with response to platinum
based chemotherapy, progression-free and overall survival in
ovarian cancer |
| title_short | Calpain-2 expression is associated with response to platinum
based chemotherapy, progression-free and overall survival in
ovarian cancer |
| title_sort | calpain-2 expression is associated with response to platinum
based chemotherapy, progression-free and overall survival in
ovarian cancer |
| url | https://eprints.nottingham.ac.uk/2786/ https://eprints.nottingham.ac.uk/2786/ https://eprints.nottingham.ac.uk/2786/ |