Synthesis and biological evaluation of novel anti-tumour (E)-styrylsulfonyl methylpyridines

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Synthesis and biological evaluation of novel anti-tumour (E)-styrylsulfonyl methylpyridines

ON01910.Na (Rigosertib, Estybon®), a styryl benzylsulfone, is a Phase III stage anti-cancer agent. This non-ATP competitive kinase inhibitor has multi-targeted activity, promoting mitotic arrest and apoptosis. Extensive Phase I/II studies with ON01910.Na, conducted in patients with solid tumours and...

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Bibliographic Details
Main Author:	Lu, Tiangong
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2014
Online Access:	https://eprints.nottingham.ac.uk/27764/

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