Study of NAP adsorption and assembly on the surface of HOPG
NAP is an octapeptide that has demonstrated a neuroprotective/therapeutic efficacy at very low concentrations in preclinical studies and in a number of clinical trials. Yet little is known about its structural organization at low concentrations. Here, we have employed atomic force microscopy to inve...
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| Format: | Article |
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Elsevier
2014
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| Online Access: | https://eprints.nottingham.ac.uk/27680/ |
| _version_ | 1848793413484281856 |
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| author | Korolkov, Vladimir V. Allen, Stephanie Roberts, Clive J. Gozes, Illana Tendler, Saul J.B. |
| author_facet | Korolkov, Vladimir V. Allen, Stephanie Roberts, Clive J. Gozes, Illana Tendler, Saul J.B. |
| author_sort | Korolkov, Vladimir V. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | NAP is an octapeptide that has demonstrated a neuroprotective/therapeutic efficacy at very low concentrations in preclinical studies and in a number of clinical trials. Yet little is known about its structural organization at low concentrations. Here, we have employed atomic force microscopy to investigate NAP peptide assembly on graphite in aqueous media at nanomolar concentration. High spatial resolution scans of NAP assemblies reveal their fine structure with clearly resolved single NAP units. This observation leads us to conclude that NAP molecules do not form complex self-assembled structures at nanomolar concentration when adsorbed on graphite surface. |
| first_indexed | 2025-11-14T18:59:54Z |
| format | Article |
| id | nottingham-27680 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:59:54Z |
| publishDate | 2014 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-276802020-05-04T16:53:13Z https://eprints.nottingham.ac.uk/27680/ Study of NAP adsorption and assembly on the surface of HOPG Korolkov, Vladimir V. Allen, Stephanie Roberts, Clive J. Gozes, Illana Tendler, Saul J.B. NAP is an octapeptide that has demonstrated a neuroprotective/therapeutic efficacy at very low concentrations in preclinical studies and in a number of clinical trials. Yet little is known about its structural organization at low concentrations. Here, we have employed atomic force microscopy to investigate NAP peptide assembly on graphite in aqueous media at nanomolar concentration. High spatial resolution scans of NAP assemblies reveal their fine structure with clearly resolved single NAP units. This observation leads us to conclude that NAP molecules do not form complex self-assembled structures at nanomolar concentration when adsorbed on graphite surface. Elsevier 2014-09-30 Article PeerReviewed Korolkov, Vladimir V., Allen, Stephanie, Roberts, Clive J., Gozes, Illana and Tendler, Saul J.B. (2014) Study of NAP adsorption and assembly on the surface of HOPG. Peptides, 62 . pp. 55-58. ISSN 0196-9781 NAP; Atomic Force Microscopy; davunetide; adsorption; peptides http://www.sciencedirect.com/science/article/pii/S0196978114002861 doi:10.1016/j.peptides.2014.09.017 doi:10.1016/j.peptides.2014.09.017 |
| spellingShingle | NAP; Atomic Force Microscopy; davunetide; adsorption; peptides Korolkov, Vladimir V. Allen, Stephanie Roberts, Clive J. Gozes, Illana Tendler, Saul J.B. Study of NAP adsorption and assembly on the surface of HOPG |
| title | Study of NAP adsorption and assembly on the surface of HOPG |
| title_full | Study of NAP adsorption and assembly on the surface of HOPG |
| title_fullStr | Study of NAP adsorption and assembly on the surface of HOPG |
| title_full_unstemmed | Study of NAP adsorption and assembly on the surface of HOPG |
| title_short | Study of NAP adsorption and assembly on the surface of HOPG |
| title_sort | study of nap adsorption and assembly on the surface of hopg |
| topic | NAP; Atomic Force Microscopy; davunetide; adsorption; peptides |
| url | https://eprints.nottingham.ac.uk/27680/ https://eprints.nottingham.ac.uk/27680/ https://eprints.nottingham.ac.uk/27680/ |