Hydrodynamic modelling of protein conformation in solution: ELLIPS and HYDRO
The last three decades has seen some important advances in our ability to represent the conformation of proteins in solution on the basis of hydrodynamic measurements. Advances in theoretical modeling capabilities have been matched by commensurate advances in the precision of hydrodynamic measu...
| Main Authors: | , |
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| Format: | Article |
| Published: |
Springer Verlag
2013
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| Online Access: | https://eprints.nottingham.ac.uk/2673/ |
| _version_ | 1848790846074257408 |
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| author | de la Torre, José García Harding, Stephen E. |
| author_facet | de la Torre, José García Harding, Stephen E. |
| author_sort | de la Torre, José García |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The last three decades has seen some important
advances in our ability to represent the conformation of
proteins in solution on the basis of hydrodynamic measurements.
Advances in theoretical modeling capabilities have
been matched by commensurate advances in the precision of
hydrodynamic measurements. We consider the advances in
whole-body (simple ellipsoid-based) modeling—still useful
for providing an overall idea of molecular shape, particularly
for those systems where only a limited amount of data is
available—and outline the ELLIPS suite of algorithms
which facilitates the use of this approach. We then focus
on bead modeling strategies, particularly the surface or
shell–bead approaches and the HYDRO suite of algorithms.
We demonstrate how these are providing great insights into
complex issues such as the conformation of immunoglobulins
and other multi-domain complexes. |
| first_indexed | 2025-11-14T18:19:06Z |
| format | Article |
| id | nottingham-2673 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:19:06Z |
| publishDate | 2013 |
| publisher | Springer Verlag |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-26732020-05-04T20:19:14Z https://eprints.nottingham.ac.uk/2673/ Hydrodynamic modelling of protein conformation in solution: ELLIPS and HYDRO de la Torre, José García Harding, Stephen E. The last three decades has seen some important advances in our ability to represent the conformation of proteins in solution on the basis of hydrodynamic measurements. Advances in theoretical modeling capabilities have been matched by commensurate advances in the precision of hydrodynamic measurements. We consider the advances in whole-body (simple ellipsoid-based) modeling—still useful for providing an overall idea of molecular shape, particularly for those systems where only a limited amount of data is available—and outline the ELLIPS suite of algorithms which facilitates the use of this approach. We then focus on bead modeling strategies, particularly the surface or shell–bead approaches and the HYDRO suite of algorithms. We demonstrate how these are providing great insights into complex issues such as the conformation of immunoglobulins and other multi-domain complexes. Springer Verlag 2013-06 Article PeerReviewed de la Torre, José García and Harding, Stephen E. (2013) Hydrodynamic modelling of protein conformation in solution: ELLIPS and HYDRO. Biophysical Reviews, 5 (2). pp. 195-206. ISSN 1867-2450 http://link.springer.com/article/10.1007%2Fs12551-013-0102-6 doi:10.1007/s12551-013-0102-6 doi:10.1007/s12551-013-0102-6 |
| spellingShingle | de la Torre, José García Harding, Stephen E. Hydrodynamic modelling of protein conformation in solution: ELLIPS and HYDRO |
| title | Hydrodynamic modelling of protein conformation
in solution: ELLIPS and HYDRO |
| title_full | Hydrodynamic modelling of protein conformation
in solution: ELLIPS and HYDRO |
| title_fullStr | Hydrodynamic modelling of protein conformation
in solution: ELLIPS and HYDRO |
| title_full_unstemmed | Hydrodynamic modelling of protein conformation
in solution: ELLIPS and HYDRO |
| title_short | Hydrodynamic modelling of protein conformation
in solution: ELLIPS and HYDRO |
| title_sort | hydrodynamic modelling of protein conformation
in solution: ellips and hydro |
| url | https://eprints.nottingham.ac.uk/2673/ https://eprints.nottingham.ac.uk/2673/ https://eprints.nottingham.ac.uk/2673/ |