Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes

Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes

Aims Long-QT syndromes (LQTS) are mostly autosomal-dominant congenital disorders associated with a 1:1000 mutation frequency, cardiac arrest, and sudden death. We sought to use cardiomyocytes derived from human-induced pluripotency stem cells (hiPSCs) as an in vitro model to develop and evaluate gen...

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Bibliographic Details
Main Authors: Matsa, Elena, Dixon, James E., Medway, Christopher, Georgiou, Orestis, Patel, Minal J., Morgan, Kevin, Kemp, Paul J., Staniforth, Andrew, Mellor, Ian, Denning, Chris
Format: Article
Published: Oxford University Press 2013
Subjects:
iPS cells
Long-QT syndrome
Arrhythmia
Electrophysiology
Gene therapy
Online Access:https://eprints.nottingham.ac.uk/2664/

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