The genetics of pre-eclampsia and other hypertensive disorders of pregnancy
Hypertension is the most frequent medical complication occurring during pregnancy. In this chapter, we aim to address the genetic contribution to these disorders, with specific focus on preeclampsia. The pathogenic mechanisms underlying pre-eclampsia remain to be elucidated; however, immune maladapt...
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| Format: | Article |
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Elsevier
2011
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| Online Access: | https://eprints.nottingham.ac.uk/2616/ |
| _version_ | 1848790831463399424 |
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| author | Williams, Paula J. Broughton Pipkin, Fiona |
| author_facet | Williams, Paula J. Broughton Pipkin, Fiona |
| author_sort | Williams, Paula J. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Hypertension is the most frequent medical complication occurring during pregnancy. In this chapter, we aim to address the genetic contribution to these disorders, with specific focus on preeclampsia. The pathogenic mechanisms underlying pre-eclampsia remain to be elucidated; however, immune maladaptation, inadequate placental development and trophoblast invasion, placental ischaemia, oxidative stress and thrombosis are all thought to represent key factors in the development of disease. Furthermore, all of these components have genetic factors that may be involved in the pathogenic changes occurring. The familial nature of pre-eclampsia has been known for many years and, as such, extensive genetic research has been carried out in this area using strategies that include candidate gene studies and linkage analysis. Interactions between fetal and maternal genotypes, the effect of environmental factors, and epistasis will also be considered. |
| first_indexed | 2025-11-14T18:18:52Z |
| format | Article |
| id | nottingham-2616 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:18:52Z |
| publishDate | 2011 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-26162020-05-04T20:23:13Z https://eprints.nottingham.ac.uk/2616/ The genetics of pre-eclampsia and other hypertensive disorders of pregnancy Williams, Paula J. Broughton Pipkin, Fiona Hypertension is the most frequent medical complication occurring during pregnancy. In this chapter, we aim to address the genetic contribution to these disorders, with specific focus on preeclampsia. The pathogenic mechanisms underlying pre-eclampsia remain to be elucidated; however, immune maladaptation, inadequate placental development and trophoblast invasion, placental ischaemia, oxidative stress and thrombosis are all thought to represent key factors in the development of disease. Furthermore, all of these components have genetic factors that may be involved in the pathogenic changes occurring. The familial nature of pre-eclampsia has been known for many years and, as such, extensive genetic research has been carried out in this area using strategies that include candidate gene studies and linkage analysis. Interactions between fetal and maternal genotypes, the effect of environmental factors, and epistasis will also be considered. Elsevier 2011-08 Article PeerReviewed Williams, Paula J. and Broughton Pipkin, Fiona (2011) The genetics of pre-eclampsia and other hypertensive disorders of pregnancy. Best Practice & Research Clinical Obstetrics and Gynaecology, 25 (4). pp. 405-417. ISSN 1521-6934 pre-eclampsia genome-wide association study pregnancy-induced hypertension http://www.bestpracticeobgyn.com/article/S1521-6934(11)00045-9/abstract doi:10.1016/j.bpobgyn.2011.02.007 doi:10.1016/j.bpobgyn.2011.02.007 |
| spellingShingle | pre-eclampsia genome-wide association study pregnancy-induced hypertension Williams, Paula J. Broughton Pipkin, Fiona The genetics of pre-eclampsia and other hypertensive disorders of pregnancy |
| title | The genetics of pre-eclampsia and other hypertensive disorders of pregnancy |
| title_full | The genetics of pre-eclampsia and other hypertensive disorders of pregnancy |
| title_fullStr | The genetics of pre-eclampsia and other hypertensive disorders of pregnancy |
| title_full_unstemmed | The genetics of pre-eclampsia and other hypertensive disorders of pregnancy |
| title_short | The genetics of pre-eclampsia and other hypertensive disorders of pregnancy |
| title_sort | genetics of pre-eclampsia and other hypertensive disorders of pregnancy |
| topic | pre-eclampsia genome-wide association study pregnancy-induced hypertension |
| url | https://eprints.nottingham.ac.uk/2616/ https://eprints.nottingham.ac.uk/2616/ https://eprints.nottingham.ac.uk/2616/ |