Assessment of tonotopically organised subdivisions in human auditory cortex using volumetric and surface-based cortical alignments
Although orderly representations of sound frequency in the brain play a guiding role in the investigation of auditory processing, a rigorous statistical evaluation of cortical tonotopic maps has so far hardly been attempted. In this report, the group-level significance of local tonotopic gradients w...
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| Format: | Article |
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Wiley
2014
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| Online Access: | https://eprints.nottingham.ac.uk/2569/ |
| _version_ | 1848790819199254528 |
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| author | Langers, Dave R.M. |
| author_facet | Langers, Dave R.M. |
| author_sort | Langers, Dave R.M. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Although orderly representations of sound frequency in the brain play a guiding role in the investigation of auditory processing, a rigorous statistical evaluation of cortical tonotopic maps has so far hardly been attempted. In this report, the group-level significance of local tonotopic gradients was assessed using mass-multivariate statistics. The existence of multiple fields on the superior surface of the temporal lobe in both hemispheres was shown. These fields were distinguishable on the basis of tonotopic gradient direction and may likely be identified with the human homologues of the core areas AI and R in primates. Moreover, an objective comparison was made between the usage of volumetric and surface-based registration methods. Although the surface-based method resulted in a better registration across subjects of the grey matter segment as a whole, the alignment of functional subdivisions within the cortical sheet did not appear to improve over volumetric methods. This suggests that the variable relationship between the structural and the functional characteristics of auditory cortex is a limiting factor that cannot be overcome by morphology-based registration techniques alone. Finally, to illustrate how the proposed approach may be used in clinical practice, the method was used to test for focal differences regarding the tonotopic arrangements in healthy controls and tinnitus patients. No significant differences were observed, suggesting that tinnitus does not necessarily require tonotopic reorganisation to occur |
| first_indexed | 2025-11-14T18:18:40Z |
| format | Article |
| id | nottingham-2569 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:18:40Z |
| publishDate | 2014 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-25692020-05-04T20:14:53Z https://eprints.nottingham.ac.uk/2569/ Assessment of tonotopically organised subdivisions in human auditory cortex using volumetric and surface-based cortical alignments Langers, Dave R.M. Although orderly representations of sound frequency in the brain play a guiding role in the investigation of auditory processing, a rigorous statistical evaluation of cortical tonotopic maps has so far hardly been attempted. In this report, the group-level significance of local tonotopic gradients was assessed using mass-multivariate statistics. The existence of multiple fields on the superior surface of the temporal lobe in both hemispheres was shown. These fields were distinguishable on the basis of tonotopic gradient direction and may likely be identified with the human homologues of the core areas AI and R in primates. Moreover, an objective comparison was made between the usage of volumetric and surface-based registration methods. Although the surface-based method resulted in a better registration across subjects of the grey matter segment as a whole, the alignment of functional subdivisions within the cortical sheet did not appear to improve over volumetric methods. This suggests that the variable relationship between the structural and the functional characteristics of auditory cortex is a limiting factor that cannot be overcome by morphology-based registration techniques alone. Finally, to illustrate how the proposed approach may be used in clinical practice, the method was used to test for focal differences regarding the tonotopic arrangements in healthy controls and tinnitus patients. No significant differences were observed, suggesting that tinnitus does not necessarily require tonotopic reorganisation to occur Wiley 2014-04 Article PeerReviewed Langers, Dave R.M. (2014) Assessment of tonotopically organised subdivisions in human auditory cortex using volumetric and surface-based cortical alignments. Human Brain Mapping, 35 (4). pp. 1544-1561. ISSN 1065-9471 topographic maps; tonotopy;cochleotopy; auditory cortex; functional magnetic resonance imaging (fMRI); registration; tinnitus; plasticity http://onlinelibrary.wiley.com/doi/10.1002/hbm.22272/abstract doi:10.1002/hbm.22272 doi:10.1002/hbm.22272 |
| spellingShingle | topographic maps; tonotopy;cochleotopy; auditory cortex; functional magnetic resonance imaging (fMRI); registration; tinnitus; plasticity Langers, Dave R.M. Assessment of tonotopically organised subdivisions in human auditory cortex using volumetric and surface-based cortical alignments |
| title | Assessment of tonotopically organised subdivisions in human auditory cortex using volumetric and surface-based cortical alignments |
| title_full | Assessment of tonotopically organised subdivisions in human auditory cortex using volumetric and surface-based cortical alignments |
| title_fullStr | Assessment of tonotopically organised subdivisions in human auditory cortex using volumetric and surface-based cortical alignments |
| title_full_unstemmed | Assessment of tonotopically organised subdivisions in human auditory cortex using volumetric and surface-based cortical alignments |
| title_short | Assessment of tonotopically organised subdivisions in human auditory cortex using volumetric and surface-based cortical alignments |
| title_sort | assessment of tonotopically organised subdivisions in human auditory cortex using volumetric and surface-based cortical alignments |
| topic | topographic maps; tonotopy;cochleotopy; auditory cortex; functional magnetic resonance imaging (fMRI); registration; tinnitus; plasticity |
| url | https://eprints.nottingham.ac.uk/2569/ https://eprints.nottingham.ac.uk/2569/ https://eprints.nottingham.ac.uk/2569/ |