Chondrocalcinosis is common in the absence of knee involvement
Introduction: We aimed to describe the distribution of radiographic chondrocalcinosis (CC) and to examine whether metacarpophalangeal joint (MCPJ) calcification and CC at other joints occurs in the absence of knee involvement. Methods: This was a cross-sectional study embedded in the Genetics o...
| Main Authors: | , , , , , |
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| Format: | Article |
| Published: |
BioMed Central Ltd
2012
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| Online Access: | https://eprints.nottingham.ac.uk/2559/ |
| _version_ | 1848790816636534784 |
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| author | Abhishek, Abishek Doherty, Sally Maciewicz, Rose Muir, Kenneth Zhang, Weiya Doherty, Michael |
| author_facet | Abhishek, Abishek Doherty, Sally Maciewicz, Rose Muir, Kenneth Zhang, Weiya Doherty, Michael |
| author_sort | Abhishek, Abishek |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Introduction: We aimed to describe the distribution of radiographic chondrocalcinosis (CC) and to examine
whether metacarpophalangeal joint (MCPJ) calcification and CC at other joints occurs in the absence of knee
involvement.
Methods: This was a cross-sectional study embedded in the Genetics of Osteoarthritis and Lifestyle study (GOAL).
All participants (n = 3,170) had radiographs of the knees, hands, and pelvis. These were scored for radiographic
changes of osteoarthritis (OA), for CC at knees, hips, symphysis pubis, and wrists, and for MCPJ calcification. The
prevalence of MCPJ calcification and CC overall, at each joint, and in the presence or absence of knee involvement,
was calculated.
Results: The knee was the commonest site of CC, followed by wrists, hips, and symphysis pubis. CC was more
likely to be bilateral at knees and wrists but unilateral at hips. MCPJ calcification was usually bilateral, and less
common than CC at knees, hips, wrists, and symphysis pubis. Unlike that previously reported, CC commonly
occurred without any knee involvement; 44.4% of wrist CC, 45.9% of hip CC, 45.5% of symphysis pubis CC, and
31.3% of MCPJ calcification occurred in patients without knee CC. Those with meniscal or hyaline articular cartilage
CC had comparable ages (P = 0.21), and neither preferentially associated with fibrocartilage CC at distant joints.
Conclusions: CC visualized on a plain radiograph commonly occurs at other joints in the absence of radiographic
knee CC. Therefore, knee radiographs alone are an insufficient screening test for CC. This has significant
implications for clinical practice, for epidemiologic and genetic studies of CC, and for the definition of OA patients
with coexistent crystal deposition. |
| first_indexed | 2025-11-14T18:18:38Z |
| format | Article |
| id | nottingham-2559 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:18:38Z |
| publishDate | 2012 |
| publisher | BioMed Central Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-25592020-05-04T16:34:34Z https://eprints.nottingham.ac.uk/2559/ Chondrocalcinosis is common in the absence of knee involvement Abhishek, Abishek Doherty, Sally Maciewicz, Rose Muir, Kenneth Zhang, Weiya Doherty, Michael Introduction: We aimed to describe the distribution of radiographic chondrocalcinosis (CC) and to examine whether metacarpophalangeal joint (MCPJ) calcification and CC at other joints occurs in the absence of knee involvement. Methods: This was a cross-sectional study embedded in the Genetics of Osteoarthritis and Lifestyle study (GOAL). All participants (n = 3,170) had radiographs of the knees, hands, and pelvis. These were scored for radiographic changes of osteoarthritis (OA), for CC at knees, hips, symphysis pubis, and wrists, and for MCPJ calcification. The prevalence of MCPJ calcification and CC overall, at each joint, and in the presence or absence of knee involvement, was calculated. Results: The knee was the commonest site of CC, followed by wrists, hips, and symphysis pubis. CC was more likely to be bilateral at knees and wrists but unilateral at hips. MCPJ calcification was usually bilateral, and less common than CC at knees, hips, wrists, and symphysis pubis. Unlike that previously reported, CC commonly occurred without any knee involvement; 44.4% of wrist CC, 45.9% of hip CC, 45.5% of symphysis pubis CC, and 31.3% of MCPJ calcification occurred in patients without knee CC. Those with meniscal or hyaline articular cartilage CC had comparable ages (P = 0.21), and neither preferentially associated with fibrocartilage CC at distant joints. Conclusions: CC visualized on a plain radiograph commonly occurs at other joints in the absence of radiographic knee CC. Therefore, knee radiographs alone are an insufficient screening test for CC. This has significant implications for clinical practice, for epidemiologic and genetic studies of CC, and for the definition of OA patients with coexistent crystal deposition. BioMed Central Ltd 2012-10-04 Article PeerReviewed Abhishek, Abishek, Doherty, Sally, Maciewicz, Rose, Muir, Kenneth, Zhang, Weiya and Doherty, Michael (2012) Chondrocalcinosis is common in the absence of knee involvement. Arthritis Research & Therapy, 14 (5). 5/1-5/5. ISSN 1478-6354 http://arthritis-research.com/content/14/5/R205/abstract doi:10.1186/ar4043 doi:10.1186/ar4043 |
| spellingShingle | Abhishek, Abishek Doherty, Sally Maciewicz, Rose Muir, Kenneth Zhang, Weiya Doherty, Michael Chondrocalcinosis is common in the absence of knee involvement |
| title | Chondrocalcinosis is common in the absence of knee involvement |
| title_full | Chondrocalcinosis is common in the absence of knee involvement |
| title_fullStr | Chondrocalcinosis is common in the absence of knee involvement |
| title_full_unstemmed | Chondrocalcinosis is common in the absence of knee involvement |
| title_short | Chondrocalcinosis is common in the absence of knee involvement |
| title_sort | chondrocalcinosis is common in the absence of knee involvement |
| url | https://eprints.nottingham.ac.uk/2559/ https://eprints.nottingham.ac.uk/2559/ https://eprints.nottingham.ac.uk/2559/ |