Specificity factors in cytoplasmic polyadenylation
Poly(A) tail elongation after export of an messenger RNA (mRNA) to the cytoplasm is called cytoplasmic polyadenylation. It was first discovered in oocytes and embryos, where it has roles in meiosis and development. In recent years, however, has been implicated in many other processes, including syna...
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| Format: | Article |
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Wiley
2013
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| Online Access: | https://eprints.nottingham.ac.uk/2526/ |
| _version_ | 1848790807907139584 |
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| author | Charlesworth, Amanda Meijer, Hedda A. de Moor, Cornelia H. |
| author_facet | Charlesworth, Amanda Meijer, Hedda A. de Moor, Cornelia H. |
| author_sort | Charlesworth, Amanda |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Poly(A) tail elongation after export of an messenger RNA (mRNA) to the cytoplasm is called cytoplasmic polyadenylation. It was first discovered in oocytes and embryos, where it has roles in meiosis and development. In recent years, however, has been implicated in many other processes, including synaptic plasticity and mitosis. This review aims to introduce cytoplasmic polyadenylation with an emphasis on the factors and elements mediating this process for different mRNAs and in different animal species. We will discuss the RNA sequence elements mediating cytoplasmic polyadenylation in the 3′ untranslated regions of mRNAs, including the CPE, MBE, TCS, eCPE, and C-CPE. In addition to describing the role of general polyadenylation factors, we discuss the specific RNA binding protein families associated with cytoplasmic polyadenylation elements, including CPEB (CPEB1, CPEB2, CPEB3, and CPEB4), Pumilio (PUM2), Musashi (MSI1, MSI2), zygote arrest (ZAR2), ELAV like proteins (ELAVL1, HuR), poly(C) binding proteins (PCBP2, αCP2, hnRNP-E2), and Bicaudal C (BICC1). Some emerging themes in cytoplasmic polyadenylation will be highlighted. To facilitate understanding for those working in different organisms and fields, particularly those who are analyzing high throughput data, HUGO gene nomenclature for the human orthologs is used throughout. Where human orthologs have not been clearly identified, reference is made to protein families identified in man. |
| first_indexed | 2025-11-14T18:18:29Z |
| format | Article |
| id | nottingham-2526 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:18:29Z |
| publishDate | 2013 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-25262020-05-04T20:19:03Z https://eprints.nottingham.ac.uk/2526/ Specificity factors in cytoplasmic polyadenylation Charlesworth, Amanda Meijer, Hedda A. de Moor, Cornelia H. Poly(A) tail elongation after export of an messenger RNA (mRNA) to the cytoplasm is called cytoplasmic polyadenylation. It was first discovered in oocytes and embryos, where it has roles in meiosis and development. In recent years, however, has been implicated in many other processes, including synaptic plasticity and mitosis. This review aims to introduce cytoplasmic polyadenylation with an emphasis on the factors and elements mediating this process for different mRNAs and in different animal species. We will discuss the RNA sequence elements mediating cytoplasmic polyadenylation in the 3′ untranslated regions of mRNAs, including the CPE, MBE, TCS, eCPE, and C-CPE. In addition to describing the role of general polyadenylation factors, we discuss the specific RNA binding protein families associated with cytoplasmic polyadenylation elements, including CPEB (CPEB1, CPEB2, CPEB3, and CPEB4), Pumilio (PUM2), Musashi (MSI1, MSI2), zygote arrest (ZAR2), ELAV like proteins (ELAVL1, HuR), poly(C) binding proteins (PCBP2, αCP2, hnRNP-E2), and Bicaudal C (BICC1). Some emerging themes in cytoplasmic polyadenylation will be highlighted. To facilitate understanding for those working in different organisms and fields, particularly those who are analyzing high throughput data, HUGO gene nomenclature for the human orthologs is used throughout. Where human orthologs have not been clearly identified, reference is made to protein families identified in man. Wiley 2013-07 Article PeerReviewed Charlesworth, Amanda, Meijer, Hedda A. and de Moor, Cornelia H. (2013) Specificity factors in cytoplasmic polyadenylation. Wiley Interdisciplinary Reviews: RNA, 4 (4). pp. 437-461. ISSN 1757-7004 http://onlinelibrary.wiley.com/doi/10.1002/wrna.1171/abstract doi:10.1002/wrna.1171 doi:10.1002/wrna.1171 |
| spellingShingle | Charlesworth, Amanda Meijer, Hedda A. de Moor, Cornelia H. Specificity factors in cytoplasmic polyadenylation |
| title | Specificity factors in cytoplasmic polyadenylation |
| title_full | Specificity factors in cytoplasmic polyadenylation |
| title_fullStr | Specificity factors in cytoplasmic polyadenylation |
| title_full_unstemmed | Specificity factors in cytoplasmic polyadenylation |
| title_short | Specificity factors in cytoplasmic polyadenylation |
| title_sort | specificity factors in cytoplasmic polyadenylation |
| url | https://eprints.nottingham.ac.uk/2526/ https://eprints.nottingham.ac.uk/2526/ https://eprints.nottingham.ac.uk/2526/ |