Ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase inhibition is synthetically lethal in XRCC1 deficient ovarian cancer cells

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Ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase inhibition is synthetically lethal in XRCC1 deficient ovarian cancer cells

Introduction Ataxia telangiectasia mutated and Rad3 Related (ATR) protein kinase is a key sensor of single-stranded DNA associated with stalled replication forks and repair intermediates generated during DNA repair. XRCC1 is a critical enzyme in single strand break repair and base excision repair....

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Bibliographic Details
Main Authors:	Sultana, Rebeka, Abdel-Fatah, Tarek, Perry, Christina, Moseley, Paul, Albarakti, Nada, Mohan, Vivek, Seedhouse, Claire, Chan, Stephan, Madhusudan, Srinivasan
Format:	Article
Published:	Public Library of Science 2013
Online Access:	https://eprints.nottingham.ac.uk/2510/

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